Evidence map›Paper›PMID 32150562›Full record

ArticlePLoS neglected tropical diseases2020

Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru.

Alexander S F Berry, Renzo Salazar-Sánchez, Ricardo Castillo-Neyra, Katty Borrini-Mayorí, Claudia Arevalo-Nieto, Claudia Chipana-Ramos, Melina Vargas-Maquera, Jenny Ancca-Juarez, César Náquira-Velarde, Michael Z Levy and 1 more

Open access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Alexander S F BerryDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0003-0353-5521
Renzo Salazar-SánchezZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
Ricardo Castillo-NeyraZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.ORCID 0000-0001-6629-2139
Katty Borrini-MayoríZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
Claudia Arevalo-NietoZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
Claudia Chipana-RamosZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
Melina Vargas-MaqueraZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
Jenny Ancca-JuarezZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
César Náquira-VelardeZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
Michael Z LevyZoonotic Disease Research Lab, One Health Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Arequipa, Peru.
Dustin BrissonDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Universidad Peruana Cayetano Heredia · PEChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Training Program in Computational GenomicsT32HG000046 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI JUNHYONG KIM, Mingyao Li · 1999 to 2026
$9.5M
PARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0M
Disrupting Vector-borne Disease Transmission in Complex Urban EnvironmentsR01AI101229 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LEVY, MICHAEL Z · 2013 to 2017
$3.1M
Phylogeographic dynamics of tick-borne pathogensR01AI142572 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRISSON, DUSTIN · 2018 to 2023
$2.4M
Phylogeographic dynamics of a vector and pathogen in a natural environmentR01AI097137 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRISSON, DUSTIN · 2012 to 2016
$1.9M
NHGRI NIH HHS T32 HG000046NIAID NIH HHS R01 AI097137NIAID NIH HHS R01 AI101229NIAID NIH HHS R01 AI142572NIAID NIH HHS T32 AI007532
6 · The paper itself

Abstract

Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems. For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates derived from vectors and non-human mammals throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks-parasites in the same block tend to be very closely related-but no population structure among blocks within districts-parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal.

Indexed as

Disease Transmission, InfectiousGenotypePhylogenyAnimalsAnimals, DomesticChagas DiseaseDisease VectorsHumansMolecular EpidemiologyPeruTrypanosoma cruzi

Identifiers

PMID32150562
PMCPMC7082062
OpenAlexW3009604942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.