Evidence map›Paper›PMID 32150289›Full record

ArticleJournal of the American Geriatrics Society2020

Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium.

Shalender Bhasin, Thomas G Travison, Todd M Manini, Sheena Patel, Karol M Pencina, Roger A Fielding, Jay M Magaziner, Anne B Newman, Douglas P Kiel, Cyrus Cooper and 19 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 424 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
424citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07255001 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Monitoring Physical Function Changes in Patients With Pancreatic Ductal Adenocarcinoma: Potential for Better Understanding of Treatment Trajectory and Survival

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2025 to 2027Enrolled50ConditionsPancreatic Ductal Adenocarcinoma (PDAC), Hand Grip StrengthArmsHand grip strength assessments using a dynamometer
NCT07437053 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Branched-chain Amino Acids to Improve Sarcopenia in Patients With Advanced Chronic Kidney Disease (BOOST-CKD)

TypeinterventionalSponsorThe University of Texas Health Science Center at San AntonioRan2026 to 2027Enrolled20ConditionsChronic Kidney Disease, SarcopeniaArmsValine, EEA
3 · Its place in the literature

Who cites it

424 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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364 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Shalender BhasinBoston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Thomas G TravisonDepartment of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
Todd M ManiniDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida.
Sheena PatelCalifornia Pacific Medical Center Research Institute, San Francisco Coordinating Center, San Francisco, California.
Karol M PencinaBoston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Roger A FieldingNutrition, Exercise, Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Jay M MagazinerDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Anne B NewmanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Douglas P KielDepartment of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Jack M GuralnikDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Jane A CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Hidenori AraiNational Center for Geriatrics and Gerontology, Obu, Japan.
Brian C ClarkDepartment of Biomedical Sciences, Division of Geriatric Medicine, Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, Ohio.
Francesco LandiDepartment of Medicine and geriatrics, Catholic University of Sacred Heart, Rome, Italy.
Laura A SchaapDepartment of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research institute, Amsterdam, The Netherlands.
Suzette L PereiraAbbott Nutrition, Abbott Laboratories, Chicago, Illinois.
Daniel RooksMuscle Group, Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
Jean WooCUHK Jockey Club Institute of Ageing, SH Ho Centre for Gerontology and Geriatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Linda J WoodhouseFaculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.
Ellen BinderDivision of Geriatrics, Washington University School of Medicine, St. Louis, Missouri.
Todd BrownDivision of Endocrinology, Diabetes, & Metabolism, Johns Hopkins University, Baltimore, Maryland.
Michelle ShardellEpidemiology and Public Health, Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland.
Quian-Li XueDivision of Geriatric Medicine and Gerontology and Center on Aging and Health, Johns Hopkins Medical Institute, Baltimore, Maryland.
Ralph B DʼAgostinoDepartment of Mathematics, Framingham Heart Study, Boston University, Boston, Massachusetts.
Denise OrwigDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Greg GorsickiDepartment of Kinesiology, Georgia Southern University.
Rosaly Correa-De-AraujoDivision of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, Maryland.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, San Francisco Coordinating Center, San Francisco, California.

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEWIS LIPSITZ · 2008 to 2026
$23.9M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
Muscle Mass and Strength Cutpoints in Persons at Risk of Mobility Disability-A1U01AG051421 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER, CAWTHON, PEGGY MANNEN · 2015 to 2017
$1.7M
Position Development Conference for Sarcopenia Definitions and OutcomesR13AG060712 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER, CAWTHON, PEGGY MANNEN · 2018 to 2018
$50k
Department of Health 10/33/04Medical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2NIA NIH HHS 1R13AG060712-01NIA NIH HHS 1UO1AG051421NIA NIH HHS P30 AG031679NIA NIH HHS R13 AG060712NIA NIH HHS U01 AG051421
6 · The paper itself

Abstract

objectivesTo develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies.

methodsThirteen position statements related to the putative components of a sarcopenia definition, informed by the SDOC analyses and literature synthesis, were reviewed by an independent international expert panel (panel) iteratively and voted on by the panel during the Sarcopenia Position Statement Conference. Four position statements related to grip strength, three to lean mass derived from dual-energy x-ray absorptiometry (DXA), and four to gait speed; two were summary statements.

resultsThe SDOC analyses identified grip strength, either absolute or scaled to measures of body size, as an important discriminator of slowness. Both low grip strength and low usual gait speed independently predicted falls, self-reported mobility limitation, hip fractures, and mortality in community-dwelling older adults. Lean mass measured by DXA was not associated with incident adverse health-related outcomes in community-dwelling older adults with or without adjustment for body size.

conclusionThe panel agreed that both weakness defined by low grip strength and slowness defined by low usual gait speed should be included in the definition of sarcopenia. These position statements offer a rational basis for an evidence-based definition of sarcopenia. The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal. J Am Geriatr Soc 68:1410-1418, 2020.

Indexed as

ConsensusMobility LimitationAbsorptiometry, PhotonAccidental FallsAgedAged, 80 and overFemaleHand StrengthHip FracturesHumansIndependent LivingMaleMortalitySarcopeniaUnited StatesWalking Speedconsensus definition of sarcopeniagrip strength cut pointslean mass cut pointsmobility disabilitysarcopenia

Identifiers

PMID32150289
PMCPMC12132920

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.