ArticleThe Journal of frailty & aging2020
ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty.
Article in The Journal of frailty & aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition · 2021Trial
- Examining the relationship between D3Cr muscle mass, physical performance, and functional limitation in postmenopausal women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.The Journal of frailty & aging · 2026Review
- Longitudinal Associations Between Biomarkers and Frailty in Older Adults: Protocol for a Scoping Review.JMIR research protocols · 2026Article
- High-sensitivity cardiac troponin I and frailty: associations with the frailty index and Fried phenotype in older women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Establishing Blood-Based Biomarkers for Sarcopenia: Current Challenges and Future Directions.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Adherence to the mediterranean diet and physical activity in relation to sarcopenia: a cross-sectional epidemiological cohort study.Aging clinical and experimental research · 2025Article
- A machine learning-based assistant tool for early frailty screening of patients receiving maintenance hemodialysis.International urology and nephrology · 2024Article
- Neurofilament-light chains (NF-L), a biomarker of neuronal damage, is increased in patients with severe sarcopenia: results of the SarcoPhAge study.Aging clinical and experimental research · 2023Article
- Review
- Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients.Journal of cachexia, sarcopenia and muscle · 2023Article
- Circulating Inflammatory, Mitochondrial Dysfunction, and Senescence-Related Markers in Older Adults with Physical Frailty and Sarcopenia: A BIOSPHERE Exploratory Study.International journal of molecular sciences · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Detraining Effects of COVID-19 Pandemic on Physical Fitness, Cytokines, C-Reactive Protein and Immunocytes in Men of Various Age Groups.International journal of environmental research and public health · 2022Article
- Machine learning for predicting readmission risk among the frail: Explainable AI for healthcare.Patterns (New York, N.Y.) · 2022Article
- Anorexia of Aging: Metabolic Changes and Biomarker Discovery.Clinical interventions in aging · 2022Review
- Biomarkers of Age-Related Frailty and Frailty Related to Diseases: An Exploratory, Cross-Sectional Analysis from the MAPT Study.The journal of nutrition, health & aging · 2022Article
- Association Between Tryptophan Metabolites, Physical Performance, and Frailty in Older Persons.International journal of tryptophan research : IJTR · 2022Article
- The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort).The Journal of frailty & aging · 2021Article
- Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era.International journal of endocrinology · 2021Review
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomarkers of frailty and sarcopenia are essential to advance the understanding of these conditions of aging and develop new diagnostic tools and effective treatments. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world -- met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia. The D3Cr dilution method, which assesses creatinine excretion as a biochemical measure of muscle mass, was suggested as a more accurate measure of functional muscle mass than assessment by dual energy x-ray absorptiometry (DXA). Proposed biomarkers of frailty include markers of inflammation, the hypothalamic-pituitary-adrenal (HPA) axis response to stress, altered glucose insulin dynamics, endocrine dysregulation, aging, and others, acknowledging the complex multisystem etiology that contributes to frailty. Lack of clarity regarding a regulatory pathway for biomarker development has hindered progress; however, there are currently several international efforts to develop such biomarkers as tools to improve the treatment of individuals presenting these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.