Evidence map›Paper›PMID 32150198›Full record

ArticleOrganic & biomolecular chemistry2020

Functionalised thermally induced phase separation (TIPS) microparticles enabled for "click" chemistry.

João C F Nogueira, Ketevan Paliashvili, Alexandra Bradford, Francesco Di Maggio, Daniel A Richards, Richard M Day, Vijay Chudasama

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

João C F NogueiraUCL Chemistry Department, University College London, Gower Street, London, WC1E 6BT, UK. v.chudasama@ucl.ac.uk.
Ketevan PaliashviliCentre for Precision Healthcare, UCL Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK. r.m.day@ucl.ac.uk.
Alexandra BradfordCentre for Precision Healthcare, UCL Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK. r.m.day@ucl.ac.uk.
Francesco Di MaggioCentre for Precision Healthcare, UCL Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK. r.m.day@ucl.ac.uk.
Daniel A RichardsUCL Chemistry Department, University College London, Gower Street, London, WC1E 6BT, UK. v.chudasama@ucl.ac.uk.
Richard M DayCentre for Precision Healthcare, UCL Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK. r.m.day@ucl.ac.uk and The Discoveries Centre for Regenerative and Precision Medicine, University College London, Gower Street, London, WC1E 6BT, UK.
Vijay ChudasamaUCL Chemistry Department, University College London, Gower Street, London, WC1E 6BT, UK. v.chudasama@ucl.ac.uk.ORCID 0000-0002-8876-3285
University College Lahore · PK

Funding

Cancer Research UK 22105
6 · The paper itself

Abstract

Due to their homogeneity, tuneable properties, low cost and ease of manufacture, thermally induced phase separation (TIPS) polymeric microparticles are emerging as an exciting class of injectable device for the treatment of damaged tissue or complex diseases, such as cancer. However, relatively little work has explored enhancing surface functionalisation of this system. Herein, we present the functionalisation of TIPS microparticles with both small molecules and an antibody fragment of Herceptin™, via a heterobifunctional pyridazinedione linker capable of participating in SPAAC "click" chemistry, and compare it to the traditional method of preparing active-targeted microparticle systems, that is, physisorption of antibodies to the microparticle surface. Antigen-binding assays demonstrated that functionalisation of microparticles with Herceptin Fab, via a pyridazinedione linker, provided an enhanced avidity to HER2+ when compared to traditional physisorption methods.

Identifiers

PMID32150198
PMCPMC7362741
OpenAlexW3010188040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.