ArticleJournal of visualized experiments : JoVE2020
Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy.
Article in Journal of visualized experiments : JoVE, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Controlling Catalyst Behavior in Lewis Acid-Catalyzed Carbonyl-Olefin Metathesis.Journal of the American Chemical Society · 2023Article
- Synthesis and characterization of trigonal bipyramidal FePolyhedron · 2021Article
- Combined Theoretical and Experimental Investigation of Lewis Acid-Carbonyl Interactions for Metathesis.ACS catalysis · 2021Article
- Investigation of Lewis Acid-Carbonyl Solution Interactions via Infrared-Monitored Titration.The Journal of organic chemistry · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lewis acid-activation of carbonyl-containing substrates is a fundamental basis for facilitating transformations in organic chemistry. Historically, characterization of these interactions has been limited to models equivalent to stoichiometric reactions. Here, we report a method utilizing in situ infrared spectroscopy to probe the solution interactions between Lewis acids and carbonyls under synthetically relevant conditions. Using this method, we were able to identify 1:1 complexation between GaCl3 and acetone and a highly ligated complex for FeCl3 and acetone. The impact of this technique on mechanistic understanding is illustrated by application to the mechanism of Lewis acid-mediated carbonyl-olefin metathesis in which we were able to observe competitive binding interactions between substrate carbonyl and product carbonyl with the catalyst.
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