Evidence map›Paper›PMID 32149607›Full record

ArticleeLife2020

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.

Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioglu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T Groves, John Kuriyan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Synergistic antiarrhythmic mechanism of IJournal of translational medicine · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Synaptic memory and CaMKII.Physiological reviews · 2023
    Review
  12. Article
  13. The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Moitrayee Bhattacharyya *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-2168-1541
Young Kwang Lee *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0003-0056-6357
Serena MuratciogluDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Baiyu QiuDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Priya NyayapatiDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Howard SchulmanPanorama Institute of Molecular Medicine, Sunnyvale, United States.
Jay T GrovesDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
John KuriyanDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-4414-5477
QB3 · USPanorama Research (United States) · US

Funding

Uncovering the molecular mechanism of learning and memory with an emphasis on Down SyndromeR00GM126145 · NIGMS · YALE UNIVERSITY · PI BHATTACHARYYA, MOITRAYEE · 2020 to 2022
$747k
Molecular mechanism for the regulation of activation in calcium/calmodulin-dependent protein kinase II (CaMKII)K99GM126145 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BHATTACHARYYA, MOITRAYEE · 2017 to 2018
$180k
Howard Hughes Medical InstituteNIGMS NIH HHS K99 GM126145NIGMS NIH HHS R00 GM126145
6 · The paper itself

Abstract

The many variants of human Ca

Indexed as

CalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CalmodulinCatalytic DomainEnzyme ActivationHumansPhosphorylationProtein IsoformsSingle Molecule ImagingCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CalmodulinCAMK2A protein, humanCAMK2B protein, humanProtein IsoformsautophosphorylationbiochemistryCaMKII isoformschemical biologyflexible linkerkinase activitymolecular biophysicsphosphatase resistancesingle-molecule microscopystructural biology

Identifiers

PMID32149607
PMCPMC7141811
OpenAlexW3012189330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.