Evidence map›Paper›PMID 32149404›Full record

SynthesisDevelopmental medicine and child neurology2021

Developmental outcomes after early surgery for complex congenital heart disease: a systematic review and meta-analysis.

Darlene Huisenga, Sacha La Bastide-Van Gemert, Andrew Van Bergen, Jane Sweeney, Mijna Hadders-Algra

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Developmental medicine and child neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 8 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 8 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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  13. Atypical Development of Functional Brain Networks in Neonates with Congenital Heart Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Darlene HuisengaDepartment of Pediatric Rehabilitation and Development, Advocate Children's Hospital, Oak Lawn, IL, USA.
Sacha La Bastide-Van GemertUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Andrew Van BergenDepartment of Pediatric Rehabilitation and Development, Advocate Children's Hospital, Oak Lawn, IL, USA.
Jane SweeneyPediatric Science Doctoral Program, Rocky Mountain University of Health Professions, Provo, UT, USA.
Mijna Hadders-AlgraUniversity of Groningen, University Medical Center Groningen, Department of Paediatrics, Division of Developmental Neurology, Groningen, the Netherlands.ORCID 0000-0001-6845-5114
University Medical Center Groningen · NLAdvocate Children's Hospital · USRocky Mountain University of Health Professions · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim(1) To systematically review the literature on developmental outcomes from infancy to adolescence of children with complex congenital heart disease (CHD) who underwent early surgery; (2) to run a meta-regression analysis on the Bayley Scales of Infant Development, Second Edition Mental Developmental Index and Psychomotor Developmental Index (PDI) of infants up to 24 months and IQs of preschool-aged children to adolescents; (3) to assess associations between perioperative risk factors and outcomes.

methodWe searched pertinent literature (January 1990 to January 2019) in PubMed, Embase, CINAHL, and PsycINFO. Selection criteria included infants with complex CHD who had primary surgery within the first 9 weeks of life. Methodological quality, including risk of bias and internal validity, were assessed.

resultsIn total, 185 papers met the inclusion criteria; the 100 with high to moderate methodological quality were analysed in detail. Substantial heterogeneity in the group with CHD and in methodology existed. The outcome of infants with single-ventricle CHD was inferior to those with two-ventricle CHD (respectively: average scores for PDI 77 and 88; intelligence scores 92 and 98). Perioperative risk factors were inconsistently associated with developmental outcomes.

interpretationThe literature on children undergoing surgery in early infancy suggests that infants with a single ventricle are at highest risk of adverse developmental outcomes.

Indexed as

IntelligencePsychomotor PerformanceAdolescentAdolescent DevelopmentCardiac Surgical ProceduresChildChild DevelopmentChild, PreschoolHeart Defects, CongenitalHumansInfantOutcome Assessment, Health Care

Identifiers

PMID32149404
PMCPMC7754445
OpenAlexW3011418460

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.