Evidence map›Paper›PMID 32149188›Full record

ArticleMedical research archives2018

The clinical impact of estrogen loss on cardiovascular disease in menopausal females.

Marissa A Lopez-Pier, Yulia Lipovka, Matthew P Koppinger, Preston R Harris, John P Konhilas

Open access · greenAbstract read
In one paragraph

Article in Medical research archives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 11 citations in OpenAlex.

  1. Understanding the Mortality Trends in Patients With Ventricular Arrhythmias and Cardiomyopathy: A 25-Year Retrospective Analysis From 1999-2024.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Observational
  2. Article
  3. Sex and ovarian hormone status shape baseline cardiovascular physiology in Sprague Dawley rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Osteoporosis and vascular calcifications.Endocrine connections · 2023
    Review
  12. Article
  13. Regulatory Role of Sex Hormones in Cardiovascular Calcification.International journal of molecular sciences · 2021
    Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marissa A Lopez-PierDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85724, U.S.A.
Yulia LipovkaDepartment of Physiology, University of Arizona, Tucson, AZ 85724, U.S.A. Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, U.S.A.
Matthew P KoppingerDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ 85724, U.S.A.
Preston R HarrisDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ 85724, U.S.A.
John P KonhilasDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85724, U.S.A.
University of Arizona · US

Funding

University of Arizona's Initiatives to Maximize Student DiversityR25GM062584 · NIGMS · UNIVERSITY OF ARIZONA · PI TAX, FRANS E · 2001 to 2017
$7.2M
Cardiovascular Biomedical Engineering Training GrantT32HL007955 · NHLBI · UNIVERSITY OF ARIZONA · PI BARTON, JENNIFER KEHLET · 2001 to 2020
$5.1M
University of Arizona's Initiative for Maximizing Student Development (IMSD)T32GM139779 · NIGMS · UNIVERSITY OF ARIZONA · PI FRANS E TAX · 2022 to 2026
$2.9M
Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathyR01HL098256 · NHLBI · UNIVERSITY OF ARIZONA · PI KONHILAS, JOHN P · 2010 to 2014
$1.9M
Metabolism, Skeletal Muscle, Cardiac Disease, ExerciseK01AR052840 · NIAMS · UNIVERSITY OF COLORADO · PI KONHILAS, JOHN P · 2006 to 2010
$600k
Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathyK02HL105799 · NHLBI · UNIVERSITY OF ARIZONA · PI KONHILAS, JOHN P · 2011 to 2015
$516k
NHLBI NIH HHS K02 HL105799NHLBI NIH HHS R01 HL098256NHLBI NIH HHS T32 HL007955NIAMS NIH HHS K01 AR052840NIGMS NIH HHS R25 GM062584NIGMS NIH HHS T32 GM139779
6 · The paper itself

Abstract

According to the CDC (2017), more women than men have died from heart disease over the last 20-25 years. On the contrary, premenopausal women are protected against heart and cardiovascular disease (CVD) compared to men. Following menopause, there is sharp rise in CVD mortality and morbidity in women compared to men indicating that women lose protection against CVD during menopause. This loss of CVD protection in women drives the CDC statistics. Life expectance of women has now reached 82 (almost 35 years longer than at the turn of the 20

Indexed as

AMP-activated protein kinasecardiovascular diseaseestrogenestrogen receptors hormone replacement therapymenopauseovariectomyperimenopausetiming hypothesis

Identifiers

PMID32149188
PMCPMC7059770
OpenAlexW2787324574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.