Evidence map›Paper›PMID 32149145›Full record

ArticleBioMed research international2020

Evaluation of the Role of Human DNAJAs in the Response to Cytotoxic Chemotherapeutic Agents in a Yeast Model System.

Aurellia Whitmore, Devon Freeny, Samantha J Sojourner, Jana S Miles, Willie M Graham, Hernan Flores-Rozas

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aurellia WhitmoreCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA.
Devon FreenyCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA.
Samantha J SojournerCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA.
Jana S MilesCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA.
Willie M GrahamCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA.
Hernan Flores-RozasCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA.ORCID https://orcid.org/0000-0003-1876-7173
Florida Agricultural and Mechanical University · US

Funding

Research Project-3: Effectiveness of an eHealth intervention for uptake of cervical cancer screening in Hispanic womenU54MD007582 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI Eunsook Yu Lee · 2019 to 2026
$28.1M
Recruitment and HiringG12MD007582 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI SOLIMAN, KARAM F.A. · 2012 to 2017
$16.0M
NIMHD NIH HHS G12 MD007582NIMHD NIH HHS U54 MD007582
6 · The paper itself

Abstract

Heat-shock proteins (HSPs) play a crucial role in maintaining protein stability for cell survival during stress-induced insults. Overexpression of HSPs in cancer cells results in antiapoptotic activity contributing to cancer cell survival and restricting the efficacy of cytotoxic chemotherapy, which continues to play an important role in the treatment of many cancers, including triple-negative breast cancer (TNBC). First-line therapy for TNBC includes anthracycline antibiotics, which are associated with serious dose-dependent side effects and the development of resistance. We previously identified

Indexed as

Antineoplastic AgentsCell SurvivalCytotoxinsHSP40 Heat-Shock ProteinsHumansSaccharomyces cerevisiae ProteinsTwo-Hybrid System TechniquesAntineoplastic AgentsCytotoxinsDNAJA1 protein, humanDNAJA2 protein, humanHSP40 Heat-Shock ProteinsSaccharomyces cerevisiae ProteinsYDJ1 protein, S cerevisiae

Identifiers

PMID32149145
PMCPMC7042521
OpenAlexW3005677970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.