Evidence map›Paper›PMID 32149085›Full record

ArticleBioMed research international2020

A Functional Polymorphism in the Promoter Region of Interleukin-12B Increases the Risk of Colorectal Cancer.

Yabin Liu, Binghui Li, Lili Wang, Dexian Kong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yabin LiuDepartment of General Surgery, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0003-4970-7069
Binghui LiDepartment of General Surgery, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0002-1791-2327
Lili WangDepartment of General Surgery, Shijiazhuang Traditional Chinese Medical Hospital, Shijiazhuang, Hebei 050051, China.ORCID https://orcid.org/0000-0002-3668-6740
Dexian KongDepartment of Endocrinology, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0003-3693-2443
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether the polymorphisms of interleukin-12B (

resultsCompared with TTAGAG/TTAGAG genotype of rs17860508, the GC/GC and TTAGAG/GC genotypes may significantly increase the risk of CRC (OR = 1.81, 95% CI = 1.18-2.78; OR = 1.46, 95% CI = 1.01-2.12, respectively). Furthermore, the mRNA levels of

conclusionThese data suggested that the rs17860508 GC/GC genotype might upregulate

Indexed as

Colorectal NeoplasmsAgedFemaleGenetic Predisposition to DiseaseHumansInterleukin-12 Subunit p40MaleMiddle AgedPolymorphism, GeneticPromoter Regions, GeneticRNA, MessengerIL12B protein, humanInterleukin-12 Subunit p40RNA, Messenger

Identifiers

PMID32149085
PMCPMC7054766
OpenAlexW3007958496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.