ReviewJournal of thoracic disease2020
Early norepinephrine use in septic shock.
Review in Journal of thoracic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Does Fluid Administration Based on Fluid Responsiveness Tests such as Passive Leg Raising Improve Outcomes in Sepsis?Current cardiology reviews · 2022Pooled it
- Timing of norepinephrine initiation in patients with septic shock: a systematic review and meta-analysis.Critical care (London, England) · 2020Pooled it
- Current and future strategies aiming at reducing catecholamine exposure in septic shock.Critical care (London, England) · 2026Review
- Bacteremia complicating urinary tract infections in hospitalized patients in a tertiary care hospital in Palestine, retrospective study.BMC infectious diseases · 2026Article
- Effect of norepinephrine on ventricular systolic function during septic shock: the ENESySS study.Journal of anesthesia, analgesia and critical care · 2026Article
- Effect of norepinephrine initiation timing on mortality in septic shock: a multicenter cohort study.BMC anesthesiology · 2026Observational
- Timing of Core Sepsis Bundle Elements Initiation in Critically Ill Patients: A Multicenter Target Trial Emulation Study.Clinical epidemiology · 2026Article
- Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Dynamic arterial elastance as a predictor of arterial pressure response to norepinephrine weaning in mechanically ventilated patients with vasoplegic syndrome-a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Review
- Early administration of norepinephrine in sepsis: Multicenter randomized clinical trial (EA-NE-S-TUN) study protocol.PloS one · 2024Article
- Prehospital pulse pressure and mortality of septic shock patients cared for by a mobile intensive care unit.BMC emergency medicine · 2023Article
- Early administration of multiple vasopressors is associated with better survival in patients with sepsis: a propensity score-weighted study.European journal of medical research · 2023Article
- Fluids and Early Vasopressors in the Management of Septic Shock: Do We Have the Right Answers Yet?Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023Review
- Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis.Frontiers in immunology · 2023Review
- Impact of norepinephrine on immunity and oxidative metabolism in sepsis.Frontiers in immunology · 2023Review
- Prediction of vasopressor requirement among hypotensive patients with suspected infection: usefulness of diastolic shock index and lactate.Clinical and experimental emergency medicine · 2022Article
- Prehospital norepinephrine administration reduces 30-day mortality among septic shock patients.BMC infectious diseases · 2022Article
- Pediatric sepsis phenotypes for enhanced therapeutics: An application of clustering to electronic health records.Journal of the American College of Emergency Physicians open · 2022Article
- The effect of norepinephrine on common carotid artery blood flow in septic shock patients.Scientific reports · 2021Observational
- The Potential Role of Extracorporeal Cytokine Removal in Hemodynamic Stabilization in Hyperinflammatory Shock.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As vascular tone depression is a hallmark of septic shock, administration of norepinephrine is logical in this setting. In this article, we provide and develop the following arguments for an early use of norepinephrine-the recommended first-line vasopressor-in septic shock: (I) prevention of prolonged severe hypotension, (II) increase in cardiac output through an increase in cardiac preload and/or contractility, (III) improvement of microcirculation and tissue oxygenation, (IV) prevention of fluid overload, and (V) improvement of outcome. Presence of a low diastolic arterial pressure as a marker of depressed vascular tone can be used as a trigger to initiate norepinephrine urgently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.