ArticleIUCrJ2020
On the mechanism of solid-state phase transitions in molecular crystals - the role of cooperative motion in (quasi)racemic linear amino acids.
Article in IUCrJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Frozen Interphase Domain and Mechanism of the Snakelike Macroscopic Motion in a Dynamic Crystal Solvate.Journal of the American Chemical Society · 2026Article
- Mechanical Transitions in Crystals: The Low-Temperature Thermosalient Transition of a Mesogenic Polyphenyl.Journal of the American Chemical Society · 2025Article
- Low Hysteresis Vanadium Dioxide Integrated on Silicon Using Complementary Metal-Oxide Semiconductor Compatible Oxide Buffer Layer.Small science · 2025Article
- Toward On-Demand Polymorphic Transitions of Organic Crystals via Side Chain and Lattice Dynamics Engineering.Journal of the American Chemical Society · 2024Article
- Identifying and controlling the order parameter for ultrafast photoinduced phase transitions in thermosalient materials.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Frustration of H-Bonding and Frustrated Packings in a Hexamorphic Crystal System with Reversible Crystal-Crystal Transitions.Journal of the American Chemical Society · 2024Article
- Bifurcated Polymorphic Transition and Thermochromic Fluorescence of a Molecular Crystal Involving Three-Dimensional Supramolecular Gear Rotation.Journal of the American Chemical Society · 2024Article
- Mechanism of Phase Transition in dl-Methionine: Determining Cooperative and Molecule-by-Molecule Transformations.ACS omega · 2024Article
- Solid-to-solid polymorphic phase transitions in two isostructural Bi(III) complexes with 1-phenylethyl-N-ethylthiosemicarbazide and halogens.Scientific reports · 2023Article
- Unraveling two distinct polymorph transition mechanisms in one n-type single crystal for dynamic electronics.Nature communications · 2023Article
- Unusual shape-preserved pathway of a core-shell phase transition triggered by orientational disorder.IUCrJ · 2023Article
- Developing methods to study conformational changes in RNA crystals using a photocaged ligand.Frontiers in molecular biosciences · 2022Article
- Article
- Distinct pathways of solid-to-solid phase transitions induced by defects: the case of dl-me-thio-nine.IUCrJ · 2021Article
- A combined approach to characterize ligand-induced solid-solid phase transitions in biomacromolecular crystals.Journal of applied crystallography · 2021Article
- Dependence of phase transition uniformity on crystal sizes characterized using birefringence.Structural dynamics (Melville, N.Y.) · 2021Article
- Article
- Article
- The Rich Solid-State Phase Behavior of l-Phenylalanine: Disappearing Polymorphs and High Temperature Forms.Crystal growth & design · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During single-crystal-to-single-crystal (SCSC) phase transitions, a polymorph of a compound can transform to a more stable form while remaining in the solid state. By understanding the mechanism of these transitions, strategies can be developed to control this phenomenon. This is particularly important in the pharmaceutical industry, but also relevant for other industries such as the food and agrochemical industries. Although extensive literature exists on SCSC phase transitions in inorganic crystals, it is unclear whether their classications and mechanisms translate to molecular crystals, with weaker interactions and more steric hindrance. A comparitive study of SCSC phase transitions in aliphatic linear-chain amino acid crystals, both racemates and quasi-racemates, is presented. A total of 34 transitions are considered and most are classified according to their structural change during the transition. Transitions without torsional changes show very different characteristics, such as transition temperature, enthalpy and free energy, compared with transitions that involve torsional changes. These differences can be rationalized using classical nucleation theory and in terms of a difference in mechanism; torsional changes occur in a molecule-by-molecule fashion, whereas transitions without torsional changes involve cooperative motion with multiple molecules at the same time.
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