ArticleIUCrJ2020
Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase.
Article in IUCrJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Carbonic Anhydrase I and II as Biomarkers and Therapeutic Targets in Human Disease: From Physiology to Clinical Translation.International journal of molecular sciences · 2026Review
- Probing anion recognition in a cobalt(II) de novo designed metalloprotein.Journal of inorganic biochemistry · 2026Article
- Crystallographic and EPR-based characterisation of CuInorganic chemistry frontiers · 2026Article
- Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production.Angewandte Chemie (International ed. in English) · 2025Article
- Diagnostic role of urinary CA-2 in urinary stones and its prediction of complications.American journal of translational research · 2022Article
- Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets.Journal of enzyme inhibition and medicinal chemistry · 2021Article
- Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase.Journal of enzyme inhibition and medicinal chemistry · 2021Review
- Mechanism of O-Atom Transfer from Nitrite: Nitric Oxide Release at Copper(II).Inorganic chemistry · 2021Article
- Erratum: Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Corrigendum.IUCrJ · 2021Article
- Comment on the articleIUCrJ · 2021Article
- The Active Site of a Prototypical "Rigid" Drug Target is Marked by Extensive Conformational Dynamics.Angewandte Chemie (International ed. in English) · 2020Article
- Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.Biophysical journal · 2020Review
- Elucidating the role of metal ions in carbonic anhydrase catalysis.Nature communications · 2020Article
- An enzyme in disguise.IUCrJ · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) promotes vasodilation through the activation of guanylate cyclase, resulting in the relaxation of the smooth muscle vasculature and a subsequent decrease in blood pressure. Therefore, its regulation is of interest for the treatment and prevention of heart disease. An example is pulmonary hypertension which is treated by targeting this NO/vasodilation pathway. In bacteria, plants and fungi, nitrite (NO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.