Evidence map›Paper›PMID 32148474›Full record

ArticleGastroenterology research and practice2020

Fasting Neurotensin Levels in Pediatric Celiac Disease Compared with a Control Cohort.

Donatella Iorfida, Monica Montuori, Chiara Maria Trovato, Claudio Tiberti, Andrea Sansone, Salvatore Cucchiara, Francesco Valitutti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Donatella IorfidaPediatric Gastroenterology and Liver Unit, Department of Maternal-Child Health and Urology, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-5288-6371
Monica MontuoriPediatric Gastroenterology and Liver Unit, Department of Maternal-Child Health and Urology, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0003-2383-5177
Chiara Maria TrovatoPediatric Gastroenterology and Liver Unit, Department of Maternal-Child Health and Urology, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0003-3869-1815
Claudio TibertiDepartment of Experimental Medicine, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-7443-4480
Andrea SansoneDepartment of Experimental Medicine, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-1210-2843
Salvatore CucchiaraPediatric Gastroenterology and Liver Unit, Department of Maternal-Child Health and Urology, Sapienza University of Rome, Italy.
Francesco ValituttiPediatric Unit, AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.ORCID https://orcid.org/0000-0002-1473-2240
Sapienza University of Rome · ITEuropean Biomedical Research Institute of Salerno · ITUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsNeurotensin (NT) is a gut hormone secreted by specific endocrine cells scattered throughout the epithelial layer of the small intestine, which has been identified as an important mediator in several gastrointestinal functions and disease conditions. Its potential involvement in celiac disease (CD) has been investigated, but there are conflicting findings. The aim of this study was to evaluate serum NT levels in children with CD at diagnosis, compared to a control group, and to investigate whether NT correlated in CD patients with symptoms, antibody response, and intestinal mucosal damage.

resultsThirty children (18 females, 2.2-15.9 years old) were enrolled. Of 25 patients who underwent endoscopy, 9 were CD patients, 13 were controls, and 3 were excluded due to nonspecific inflammation at duodenal biopsy. CD was diagnosed in 5 patients without biopsy. NT median was higher in CD patients compared to controls (13.25 (IQR 9.4-17.5) pg/ml vs. 7.8 (IQR 7.6-10) pg/ml;

conclusionsTo our knowledge, this is the first study that evaluates NT in CD children from Italy. Results show that NT is higher in the serum of CD children at diagnosis compared to controls. However, larger-scale studies are required to validate these findings. Whether serum NT levels can be an adjunctive marker for pediatric CD remains currently elusive.

Identifiers

PMID32148474
PMCPMC7056991
OpenAlexW3007568330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.