ArticleJournal of ginseng research2020
Fermented ginseng extract, BST204, disturbs adipogenesis of mesenchymal stem cells through inhibition of S6 kinase 1 signaling.
Article in Journal of ginseng research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Effects of the purified dry extract of fermented ginseng BST204 on muscle fiber regeneration.Biochemistry and biophysics reports · 2023Article
- Rg3 and Rh2 ginsenosides suppress embryoid body formation by inhibiting the epithelial-mesenchymal transition.Archives of pharmacal research · 2022Article
- Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Journal of ginseng research · 2022Article
- Preventive Effect ofPlants (Basel, Switzerland) · 2021Article
- Combined Anti-Adipogenic Effects of Hispidulin andBiomolecules · 2021Article
- Phytochemical Investigation of Bioactive Compounds from White Kidney Beans (Fruits ofPlants (Basel, Switzerland) · 2021Article
- Withasomniferol D, a New Anti-Adipogenic Withanolide from the Roots of Ashwagandha (Pharmaceuticals (Basel, Switzerland) · 2021Article
- Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba.Archives of pharmacal research · 2021Article
- Phytochemical Analysis of the Fruits of Sea Buckthorn (Plants (Basel, Switzerland) · 2021Article
- Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Biomedicines · 2021Article
- Fermented Ginseng Extract, BST204, Suppresses Tumorigenesis and Migration of Embryonic Carcinoma through Inhibition of Cancer Stem Cell Properties.Molecules (Basel, Switzerland) · 2020Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition of the S6 kinase 1 (S6K1) signaling pathway.
methodsThe inhibitory effects of BST204 on S6K1 signaling were investigated by immunoblot, nuclear fractionation, immunoprecipitation analyses. The antiadipogenic effect of BST204 was evaluated by measuring mRNA levels of adipogenic genes and by chromatin immunoprecipitation and quantitative real-time polymerase chain reaction analysis.
resultsTreatment with BST204 inhibited activation and nuclear translocation of S6K1, further decreasing the interaction between S6K1 and histone H2B in 10T1/2 mesenchymal stem cells. Subsequently, phosphorylation of H2B at serine 36 (H2BS36p) by S6K1 was reduced by BST204, inducing an increase in the mRNA expression of
conclusionOur results indicate that BST204 blocks adipogenesis of mesenchymal stem cells through the inhibition of S6K1-mediated histone phosphorylation. This study suggests the potential therapeutic strategy using BST204 to combat obesity and musculoskeletal diseases.
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