ArticleHypertension (Dallas, Tex. : 1979)2020
Trends in Antihypertensive Medication Monotherapy and Combination Use Among US Adults, National Health and Nutrition Examination Survey 2005-2016.
Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Effects of Intensive Blood Pressure Treatment on Orthostatic Hypotension : A Systematic Review and Individual Participant-based Meta-analysis.Annals of internal medicine · 2021Pooled it
- Low-Dose TEL/AML/CHTD SPC Versus Standard-Dose TEL in Hypertension: Phase III RCT.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Blockade of Angiotensin II Receptor Type 1 Abolishes the Erythropoietin Response to Exercise.Function (Oxford, England) · 2025Trial
- Efficacy and safety of a four-drug, quarter-dose treatment for hypertension: the QUARTET USA randomized trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- Process Evaluation of a Double-Blind Randomized Controlled Trial to Assess the Efficacy and Safety of a Quadruple Ultra-Low-Dose Treatment for Hypertension Within a Federally Qualified Health Center Network (QUARTET USA).Journal of the American Heart Association · 2024Trial
- A Randomized, Multicenter, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Quadruple Combination of Amlodipine, Losartan, Rosuvastatin, and Ezetimibe in Patients with Concomitant Essential Hypertension and Dyslipidemia.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023Trial
- Antihypertensive Medication Regimens Used in the Systolic Blood Pressure Intervention Trial.Hypertension (Dallas, Tex. : 1979) · 2023Trial
- One Pill to Rule Them All: The Role of Single-Pill Combinations in Optimizing Blood Pressure Control.Journal of general internal medicine · 2026Review
- Addressing barriers to using fixed-dose combination antihypertensive medications: lessons from the Million Hearts initiative.Journal of human hypertension · 2026Review
- Why wait? the case for up-front single-pill combination therapy in stage 1 hypertension.Journal of human hypertension · 2026Review
- Medicaid coverage for fixed-dose combination antihypertensive medications - fifty states and Washington, D.C., 2022.Journal of human hypertension · 2026Article
- Trends in Antihypertensive Medication Use and Blood Pressure Control in Adults Aged 66-79: Results of the National Examination Surveys DEGS1 and Study on Health of Older People Gesundheit 65.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Evolution in the targets for blood pressure treatment.Current opinion in nephrology and hypertension · 2026Review
- Prescription Trends of Initial Antihypertensive Medications Among Presumed Treatment-Naïve Individuals in Korea: A Retrospective Analysis.Journal of Korean medical science · 2026Article
- Is the effect of antihypertensive drug therapy on blood pressure control and prevalent cardiovascular disease associated with dietary sodium-potassium ratio? A cross-sectional study based on NHANES.Frontiers in cardiovascular medicine · 2026Article
- Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Frequency of Antihypertensive Drug Classes and Single-Pill Combinations in Obese Patients: An 8-Year Retrospective Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular outcomes in older adults with type 2 diabetes mellitus: a target trial emulation study.Cardiovascular diabetology · 2025Article
- Trends in Blood Pressure Control among US Adults With Hypertension, 2013-2014 to 2021-2023.American journal of hypertension · 2025Article
- Estimating the economic impact of blister-packaging on medication adherence and health care costs for a Medicare Advantage health plan.Journal of managed care & specialty pharmacy · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Blood pressure (BP) control rates among US adults taking antihypertensive medication have not increased over the past decade. Many adults require 2 or more classes of antihypertensive medication to achieve guideline-recommended BP goals, but the proportion of US adults taking antihypertensive medication monotherapy, versus combination therapy, has not been quantified using contemporary data. We analyzed data from 2005 to 2008, 2009 to 2012, and 2013 to 2016 National Health and Nutrition Examination Surveys to determine trends in monotherapy and combinations of antihypertensive medication classes among US adults age ≥20 years with hypertension taking antihypertensive medication (n=7837). The proportion of US adults taking antihypertensive medication with uncontrolled BP (ie, systolic BP ≥140 or diastolic BP ≥90 mm Hg) was 32.3%, 30.2%, and 31.0% in 2005 to 2008, 2009 to 2012, and 2013 to 2016, respectively (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.