Evidence map›Paper›PMID 32148076›Full record

SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2020

Pregnancy and Delivery Outcomes Following Benzodiazepine Exposure: A Systematic Review and Meta-analysis.

Sophie Grigoriadis, Lisa Graves, Miki Peer, Lana Mamisashvili, Myuri Ruthirakuhan, Parco Chan, Mirna Hennawy, Supriya Parikh, Simone Natalie Vigod, Cindy-Lee Dennis and 7 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Guideline
  4. Pooled it
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  8. Guideline
  9. Review
  10. Article
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  12. Review
  13. Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome.Advances in experimental medicine and biology · 2026
    Review
  14. Review
  15. Article
  16. Observational
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sophie GrigoriadisDepartment of Psychiatry, 71545Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.ORCID 0000-0003-3461-6850
Lisa GravesDepartment of Family and Community Medicine, Homer Stryker MD School of Medicine, 4175Western Michigan University, Kalamazoo, MI, USA.
Miki PeerEvaluative Clinical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
Lana MamisashviliEvaluative Clinical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
Myuri RuthirakuhanDepartment of Pharmacology and Toxicology, 282299Sunnybrook Research Institute, University of Toronto, Ontario, Canada.
Parco ChanDepartment of Pharmacology and Toxicology, 282299Sunnybrook Research Institute, University of Toronto, Ontario, Canada.
Mirna HennawyHurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Ontario, Canada.
Supriya ParikhHurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Ontario, Canada.
Simone Natalie VigodDepartment of Psychiatry, University of Toronto, Ontario, Canada.
Cindy-Lee DennisLawrence S. Bloomberg Faculty of Nursing, 7938University of Toronto, Ontario, Canada.
Meir SteinerDepartment of Psychiatry & Behavioural Neurosciences, St. Joseph's Healthcare Hamilton, McMaster University, Ontario, Canada.
Cara BrownDepartment of Psychiatry, University of Toronto, Ontario, Canada.
Amy CheungDepartment of Psychiatry, 71545Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
Hiltrud Dawson67136Health Nexus, Toronto, Ontario, Canada.
Neil RectorDepartment of Psychiatry, 71545Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
Melanie GuenetteEvaluative Clinical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
Margaret RichterDepartment of Psychiatry, 71545Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

Funding

CIHR
6 · The paper itself

Abstract

objectiveUnderstanding the effects of benzodiazepines (BZDs) on maternal/fetal health remains incomplete despite their frequent use. This article quantifies the effects of antenatal BZD exposure on delivery outcomes.

methodsDATA SOURCES: Medline, PsycINFO, CINAHL, Embase, and the Cochrane Library were searched till June 30, 2018. STUDY SELECTION: English-language cohort studies comparing antenatal BZD exposure to an unexposed group on any delivery outcome were eligible. In all, 23,909 records were screened, 56 studies were assessed, and 14 studies were included. DATA EXTRACTION: Two reviewers independently assessed quality and extracted data. Estimates were pooled using random effects meta-analysis. Sub-analyses examined several potential moderators including timing of exposure.

resultsThere were 9 outcomes with sufficient data for meta-analysis. Antenatal BZD exposure was significantly associated with increased risk of 6 outcomes initially: spontaneous abortion (pooled odds ratio = 1.86; 95% confidence interval [CI], 1.43 to 2.42), preterm birth (1.96; 95% CI, 1.25 to 3.08), low birth weight (2.24; 95% CI, 1.41 to 3.88), low Apgar score (2.19; 95% CI, 1.94 to 2.47), Neonatal Intensive Care Unit (NICU) admission (2.61; 95% CI, 1.64 to 4.14), and induced abortion (2.04; 95% CI, 1.23 to 3.40). There was significant heterogeneity between studies for most outcomes without consistent moderators. Birth weight (mean difference [MD]: -151.35 g; 95% CI, -329.73 to 27.03), gestational age (-0.49 weeks; 95% CI, -1.18 to 0.19), and small for gestational age (SGA; 1.42; 95% CI, 1.00 to 2.01) did not show significant associations although after adjusting for publication bias, gestational age, and SGA became significant, totaling 8 significant outcomes.

conclusionsAntenatal BZD exposure appears to be statistically associated with increased risk of several adverse perinatal outcomes. Although confounds cannot be ruled out, NICU admission does appear clinically relevant and consistent with the antidepressant literature.

Indexed as

Pregnancy OutcomePremature BirthAdultAntidepressive AgentsBenzodiazepinesFemaleHumansInfant, NewbornMaternal ExposurePregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsAntidepressive AgentsBenzodiazepinesbenzodiazepinesdeliveryfetus/neonatalmaternaloutcomespregnancy

Identifiers

PMID32148076
PMCPMC7658418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.