Evidence map›Paper›PMID 32147975›Full record

ArticlePhysiological reports2020

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine.

Aziza El Harchi, Andrew S Butler, Yihong Zhang, Christopher E Dempsey, Jules C Hancox

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aziza El HarchiSchool of Physiology and Pharmacology and Neuroscience, Biomedical Sciences Building, The University of Bristol, University Walk, Bristol, UK.ORCID 0000-0003-3329-6234
Andrew S ButlerSchool of Physiology and Pharmacology and Neuroscience, Biomedical Sciences Building, The University of Bristol, University Walk, Bristol, UK.ORCID 0000-0003-4362-940X
Yihong ZhangSchool of Physiology and Pharmacology and Neuroscience, Biomedical Sciences Building, The University of Bristol, University Walk, Bristol, UK.
Christopher E DempseySchool of Biochemistry, Biomedical Sciences Building, The University of Bristol, University Walk, Bristol, UK.ORCID 0000-0002-1933-7805
Jules C HancoxSchool of Physiology and Pharmacology and Neuroscience, Biomedical Sciences Building, The University of Bristol, University Walk, Bristol, UK.ORCID 0000-0002-2055-6482
University of Bristol · GB

Funding

British Heart Foundation PG/17/89/33414
6 · The paper itself

Abstract

The macrolide antibiotic erythromycin has been associated with QT interval prolongation and inhibition of the hERG-encoded channels responsible for the rapid delayed rectifier K

Indexed as

Antipsychotic AgentsBinding SitesERG1 Potassium ChannelErythromycinHEK293 CellsHistamine H1 Antagonists, Non-SedatingHumansInhibitory Concentration 50MacrolidesPatch-Clamp TechniquesTerfenadineThioridazineAntipsychotic AgentsERG1 Potassium ChannelErythromycinHistamine H1 Antagonists, Non-SedatingKCNH2 protein, humanMacrolidesTerfenadineThioridazineallosteric interactionBeKm-1erythromycinhERGlong QTpotassium channel

Identifiers

PMID32147975
PMCPMC7061092
OpenAlexW3011947439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.