ArticleJournal of neuroscience research2021
The impact of aging on the subregions of the fusiform gyrus in healthy older adults.
Article in Journal of neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Differences in structural brain morphometry between musicians and non-musicians.Frontiers in human neuroscience · 2025Article
- Structural brain changes in emotion recognition across the adult lifespan.Social cognitive and affective neuroscience · 2023Article
- DNA methylation of the oxytocin receptor interacts with age to impact neural response to social stimuli.Frontiers in aging neuroscience · 2023Article
- Degree centrality and functional connections in presbycusis with and without cognitive impairments.Brain imaging and behavior · 2022Article
- For whom the bell tolls: psychopathological and neurobiological correlates of a DNA methylation index of time-to-death.Translational psychiatry · 2022Article
- Genetic Association Between Epigenetic Aging-Acceleration and the Progression of Mild Cognitive Impairment to Alzheimer's Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Aberrant brain functional network strength related to cognitive impairment in age-related hearing loss.Frontiers in neurology · 2022Article
- Reorganization of brain structural networks in aging: A longitudinal study.Journal of neuroscience research · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The fusiform gyrus is known to decrease in size with increasing age. However, reported findings are inconsistent and existing studies differ in terms of the cohorts examined and/or the methods applied. Here, we analyzed age-related links in four distinct subregions of the fusiform gyrus through integrating imaging-based intensity information with microscopically defined cytoarchitectonic probabilities. In addition to age effects we investigated sex effects as well as age-by-sex interactions in a relatively large sample of 468 healthy subjects (272 females/196 males) covering a broad age range (42-97 years). We observed significant negative correlations between age and all four subregions of the fusiform gyrus indicating volume decreases over time, albeit with subregion-specific trajectories. Additionally, we observed significant negative quadratic associations with age for some subregions, suggesting an accelerating volume loss over time. These findings may serve as a frame of reference for future cross-sectional as well as longitudinal studies, not only for normative samples but also potentially for clinical conditions that present with abnormal atrophy of the fusiform gyrus. We did not detect any significant sex differences or sex-by-age interactions, suggesting that the size of the fusiform gyrus is similar in male and female brains and that age-related atrophy follows a similar trajectory in both men and women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.