ArticleJournal of clinical laboratory analysis2020
Association of IGF-1 gene rs2195239 polymorphism with the risk and clinical features of gastric cancer in a Chinese Han population.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Insulin-like growth factor-1 positively associated with bone formation markers and creatine kinase in adults with general physical activity.Journal of clinical laboratory analysis · 2021Article
- Association of IGF-1 gene rs2195239 polymorphism with the risk and clinical features of gastric cancer in a Chinese Han population.Journal of clinical laboratory analysis · 2020Article
- Association of IGF-1 gene rs2195239 polymorphism with the risk and clinical features of gastric cancer in a Chinese Han population.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a Japanese study investigated the relationship between insulin-like growth factor-1 (IGF-1) gene rs2195239 polymorphism and gastric cancer (GC) risk and found rs2195239 polymorphism did not relate with the risk of GC. However, no Chinese studies have addressed this relationship until now. Thus, the aims of this study were to demonstrate whether IGF-1 gene rs2195239 polymorphism was linked with the risk and clinical features of GC in a Chinese Han population.
methodsIn order to verify the link between IGF-1 gene rs2195239 polymorphism and GC risk, we recruited 361 GC cases and 418 controls in this case-control study. The genotyping was done by use of a custom-by-design 48-Plex SNP scan TM Kit.
resultsThis study found that IGF-1 gene rs2195239 polymorphism decreased the risk of GC. Stratified analyses suggested that the significant association was shown in the females, non-smokers, non-drinkers, and age <60 years groups for GC. In addition, IGF-1 gene rs2195239 polymorphism correlated with the tumor size, tumor clinical stage, and pathological types for GC patients.
conclusionTo sum up, this study shows that IGF-1 gene rs2195239 polymorphism is associated with the risk and clinical features of GC patients in this Chinese population.
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