ArticleCerebral cortex (New York, N.Y. : 1991)2020
Spatiotemporal Differences in the Regional Cortical Plate and Subplate Volume Growth during Fetal Development.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Fetal MRI reveals altered prenatal cortical surface area in fetuses later diagnosed with autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Normative growth trajectories of fetal brain regions validated by satisfactory maturation of neurodevelopmental domains at 2 years of age.Nature communications · 2026Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Molecular signatures of cortical expansion in the human foetal brain.Nature communications · 2024Article
- Molecular signatures of cortical expansion in the human fetal brain.bioRxiv : the preprint server for biology · 2024Article
- Divergent growth of the transient brain compartments in fetuses with nonsyndromic isolated clefts involving the primary and secondary palate.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Automatic cortical surface parcellation in the fetal brain using attention-gated spherical U-net.Frontiers in neuroscience · 2024Article
- Atypical fetal brain development in fetuses with non-syndromic isolated musculoskeletal birth defects (niMSBDs).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A revised perspective on the evolution of the lateral frontal cortex in primates.Science advances · 2023Article
- Abnormal development of transient fetal zones in mild isolated fetal ventriculomegaly.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Functional connectivity for the language network in the developing brain: 30 weeks of gestation to 30 months of age.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- In Utero MRI Identifies Impaired Second Trimester Subplate Growth in Fetuses with Congenital Heart Disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Automated 3D Fetal Brain Segmentation Using an Optimized Deep Learning Approach.AJNR. American journal of neuroradiology · 2022Article
- Association between Quantitative MR Markers of Cortical Evolving Organization and Gene Expression during Human Prenatal Brain Development.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Emerging magnetic resonance imaging techniques in open spina bifida in utero.European radiology experimental · 2021Review
- A Deep Attentive Convolutional Neural Network for Automatic Cortical Plate Segmentation in Fetal MRI.IEEE transactions on medical imaging · 2021Article
- Cortical morphology at birth reflects spatiotemporal patterns of gene expression in the fetal human brain.PLoS biology · 2020Article
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9 authors.
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Abstract
The regional specification of the cerebral cortex can be described by protomap and protocortex hypotheses. The protomap hypothesis suggests that the regional destiny of cortical neurons and the relative size of the cortical area are genetically determined early during embryonic development. The protocortex hypothesis suggests that the regional growth rate is predominantly shaped by external influences. In order to determine regional volumes of cortical compartments (cortical plate (CP) or subplate (SP)) and estimate their growth rates, we acquired T2-weighted in utero MRIs of 40 healthy fetuses and grouped them into early (<25.5 GW), mid- (25.5-31.6 GW), and late (>31.6 GW) prenatal periods. MRIs were segmented into CP and SP and further parcellated into 22 gyral regions. No significant difference was found between periods in regional volume fractions of the CP or SP. However, during the early and mid-prenatal periods, we found significant differences in relative growth rates (% increase per GW) between regions of cortical compartments. Thus, the relative size of these regions are most likely conserved and determined early during development whereas more subtle growth differences between regions are fine-tuned later, during periods of peak thalamocortical growth. This is in agreement with both the protomap and protocortex hypothesis.
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