ArticleThe Journal of infectious diseases2020
Frailty Hinders Recovery From Influenza and Acute Respiratory Illness in Older Adults.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The trial behind it
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial.The Journal of infectious diseases · 2026Trial
- Influenza.Nature reviews. Disease primers · 2026Review
- Association of Frailty and Frailty Trajectory with Risk for Respiratory Infectious Diseases.Emerging infectious diseases · 2026Article
- Exposure to Quaternary Ammonium Compounds (QACs) in Assisted Living Facilities: Implications for Older Adults.Environmental science & technology · 2026Article
- State-of-the-art of the high dose influenza vaccine in Spain.Frontiers in immunology · 2026Review
- Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol.BMC geriatrics · 2025Observational
- Potential of biomarkers of ageing in predicting severity of influenza virus infection and vaccination efficacy.npj aging · 2025Review
- Relationship Between Frailty and Respiratory Syncytial Virus Infection in Hospitalized Older Adults.Open forum infectious diseases · 2025Article
- Integrated Lung, Diaphragm and Lower Limb Muscular Ultrasound: Clinical Correlations in Geriatric Patients with Acute Respiratory Illness.Diagnostics (Basel, Switzerland) · 2025Article
- Summary of the National Advisory Committee on Immunization (NACI) Supplemental Guidance on Influenza Vaccination in Adults 65 Years of Age and Older.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2024Article
- Podcast: Need for Quality Evidence for Decision-Making on Seasonal Influenza Vaccines.Infectious diseases and therapy · 2024Article
- Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Latin America: An Expert Perspective on Knowledge Gaps.Pulmonary therapy · 2024Review
- Risk factors associated with functional decline in older hospital survivors with acute lower respiratory tract infections: a prospective cohort study.BMC geriatrics · 2024Article
- A vicious cycle of frailty and acute lower respiratory infection among community-dwelling adults (≥ 60 years): Findings from a multi-site INSPIRE cohort study, India.PLOS global public health · 2024Article
- Modelling lifespan reduction in an exogenous damage model of generic disease.Scientific reports · 2023Article
- The impact of respiratory infections and probiotic use on the nasal microbiota of frail residents in long-term care homes.ERJ open research · 2023Article
- Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness.Open forum infectious diseases · 2023Article
- Association of frailty with influenza and hospitalization due to influenza among independent older adults: a longitudinal study of Japan Gerontological Evaluation Study (JAGES).BMC geriatrics · 2023Article
- Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults.Influenza and other respiratory viruses · 2022Article
Corrections and comments
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Authors and funding
15 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundWe examined frailty as a predictor of recovery in older adults hospitalized with influenza and acute respiratory illness.
methodsA total of 5011 patients aged ≥65 years were admitted to Canadian Serious Outcomes Surveillance Network hospitals during the 2011/2012, 2012/2013, and 2013/2014 influenza seasons. Frailty was measured using a previously validated frailty index (FI). Poor recovery was defined as death by 30 days postdischarge or an increase of more than 0.06 (≥2 persistent new health deficits) on the FI. Multivariable logistic regression controlled for age, sex, season, influenza diagnosis, and influenza vaccination status.
resultsMean age was 79.4 (standard deviation = 8.4) years; 53.1% were women. At baseline, 15.0% (n = 750) were nonfrail, 39.3% (n = 1971) were prefrail, 39.8% (n = 1995) were frail, and 5.9% (n = 295) were most frail. Poor recovery was experienced by 21.4%, 52.0% of whom had died. Frailty was associated with lower odds of recovery in all 3 seasons: 2011/2012 (odds ratio [OR] = 0.70; 95% confidence interval [CI], 0.59-0.84), 2012/2013 (OR = 0.72; 95% CI, 0.66-0.79), and 2013/2014 (OR = 0.75; 95% CI, 0.69-0.82); results varied by season, influenza status, vaccination status, and age.
conclusionsIncreasing frailty is associated with lower odds of recovery, and persistent worsening frailty is an important adverse outcome of acute illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.