Evidence map›Paper›PMID 32147601›Full record

ArticleAging2020

Role of eotaxin-1/CCL11 in sepsis-induced myocardial injury in elderly patients.

Ying Li, Youguang Zhao, Chenming Qiu, Yuanrui Yang, Guihua Liao, Xi Wu, Xiaowan Zhang, Qian Zhang, Ru Zhang, Zhang Wang

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying LiDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Youguang ZhaoDepartment of Urology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Chenming QiuDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Yuanrui YangDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Guihua LiaoDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Xi WuDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Xiaowan ZhangDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Qian ZhangDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Ru ZhangDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.
Zhang WangDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial injury is a serious complication of sepsis. The present study aimed to identify potential biomarkers of sepsis-induced myocardial injury. Differentially expressed genes (DEGs) in patients and mice with sepsis-induced myocardial injury were identified via bioinformatic analysis. The identified DEG was tested in elderly patients with sepsis-induced myocardial injury. We identified 19 co-expressed DEGs. The most significant DEG was eotaxin-1/CCL11. We enrolled 25 controls without infections and 28 patients with sepsis-induced myocardial injury. Six of patients died within 30 days. Circulating eotaxin-1/CCL11 levels were significantly higher in patients with sepsis-induced myocardial injury than controls and were higher in non-survivors than survivors (both

Indexed as

AgedAged, 80 and overBiomarkersCardiomyopathiesChemokine CCL11FemaleHumansLeukocyte CountMaleNatriuretic Peptide, BrainPrognosisSepsisSurvival RateTroponin IBiomarkersChemokine CCL11Natriuretic Peptide, BrainTroponin IbiomarkerCCL11eotaxin-1sepsisseptic cardiomyopathy

Identifiers

PMID32147601
PMCPMC7093174
OpenAlexW3012381483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.