Evidence map›Paper›PMID 32146943›Full record

ReviewGastrointestinal endoscopy clinics of North America2020

Personalized Approach in the Work-up and Management of Gastroesophageal Reflux Disease.

Rena Yadlapati, John E Pandolfino

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastrointestinal endoscopy clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Guideline
  3. Patients Presenting With Reflux Symptoms - Whom to Test and Whom to Treat?The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Review
  4. Step 1 Approach for Patients With Reflux Symptoms: Whom to Test and Whom to Treat?The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Article
  5. Review
  6. Article
  7. Magnetic sphincter augmentation: considerations for use in Barrett's esophagus.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023
    Article
  8. Article
  9. Article
  10. Distinct Clinical Physiologic Phenotypes of Patients With Laryngeal Symptoms Referred for Reflux Evaluation.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Article
  11. Article
  12. Association of patient gender and gastroenterologists' diagnosis and management choices in gastroesophageal reflux disease.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rena YadlapatiDivision of Gastroenterology, University of California San Diego, 9500 Gilman Drive MC 0956, La Jolla, CA 92093, USA. Electronic address: ryadlapati@ucsd.edu.
John E PandolfinoDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Chicago, IL 60611, USA.

Funding

Role of altered response to volumetric distension in esophageal diseaseP01DK117824 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PANDOLFINO, JOHN E · 2018 to 2022
$7.3M
Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of GERDR01DK092217 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JOHN E PANDOLFINO · 2012 to 2026
$5.0M
The mechanics of symptom generation in dysphagiaR01DK079902 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PANDOLFINO, JOHN E · 2009 to 2017
$2.9M
NIDDK NIH HHS P01 DK117824NIDDK NIH HHS R01 DK079902NIDDK NIH HHS R01 DK092217
6 · The paper itself

Abstract

Patients with gastroesophageal reflux disease (GERD) present with heterogeneous symptoms, response to treatment, and physiologic profiles, requiring distinct and personalized management. This article provides a stepwise framework to phenotype GERD beginning with (1) characterization of symptom profile and response to acid suppression; (2) endoscopic evaluation of mucosal and anatomic integrity; (3) ambulatory reflux monitoring to characterize reflux burden and sensitivity; and (4) esophageal physiologic testing to assess gastroesophageal reflux mechanism and effectors of reflux clearance, and evaluate for alternate causes.

Indexed as

Disease ManagementAgedEsophageal pH MonitoringFemaleGastroesophageal RefluxHumansMaleMiddle AgedPhenotypePrecision MedicineProton Pump InhibitorsProton Pump InhibitorsEsophageal manometryEsophagitisFunctional heartburnHiatal herniaProton pump inhibitorRefluxSupragastric belchingTransient lower esophageal sphincter relaxation

Identifiers

PMID32146943
PMCPMC7083512

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.