Evidence map›Paper›PMID 32146710›Full record

ArticleHead and neck pathology2020

Prevalence and Detection of Sexually Transmitted Cases of Laryngeal Carcinoma.

Mohammad Abdulhameed Al-Qudah, Ala'a Fuad Al-Shaikh, Husam Kamel Haddad, Mohammad Abdelatif Elhassan, Osman Basheir Elhassan, Melad Nabeel Dababneh, Anas Wasef Zaitoun, Nawwaf Saleh Al Ghamdi, Bara'a Yousef Al-Najjar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. The association between lncRNA H19 and EZH2 expression in patients with EBV-positive laryngeal carcinoma.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mohammad Abdulhameed Al-QudahDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan. m.alqudah12@just.edu.jo.ORCID http://orcid.org/0000-0001-6877-1184
Ala'a Fuad Al-ShaikhMinistry of Health, Amman, 11118, Jordan.
Husam Kamel HaddadDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Mohammad Abdelatif ElhassanDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Osman Basheir ElhassanDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Melad Nabeel DababnehDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Anas Wasef ZaitounJordan University of Science and Technology, Irbid, 22110, Jordan.
Nawwaf Saleh Al GhamdiJordan University of Science and Technology, Irbid, 22110, Jordan.
Bara'a Yousef Al-NajjarJordan University of Science and Technology, Irbid, 22110, Jordan.
Jordan University of Science and Technology · JOMinistry of Health · JO

Funding

Jordan University of Science and Technology - Deanship of Research 20150359
6 · The paper itself

Abstract

introductionHuman papillomavirus (HPV) is among the reported etiologies of laryngeal squamous cell carcinoma (LSCC). Understanding the impact of HPV on LSCC may help reduce its incidence. This study investigates the association between HPV and LSCC as well as the roles for different immunohistochemical stains in HPV detection.

methodsA total of fifty-two formalin-fixed, paraffin-embedded tissue samples of LSCC, diagnosed between 2005 and 2015, were obtained from the archives of the Pathology Department. The samples were stained and processed to evaluate the relationship of HPV to LSCC.

resultsPatients had a mean age of 65.02 ± 14.341 years. By polymerase chain reaction (PCR), high-risk strains of HPV were detected in 15.4% of tissue samples. HPV-16 was found in 75% of the positive samples for an overall prevalence of 13.5%. P16 immunostaining was positive in 15.4% of cases while cyclin B and cyclin E were positive in 65.4% and 76.9%, respectively. Over half of the cases were histologically graded as moderately-differentiated, 28.8% as well-differentiated, and 15.4% as poorly-differentiated. DISCUSSION: The prevalence of HPV-positive LSCC was lower than previously stated in the literature. HPV-16 was the most commonly detected subtype, in concordance with the findings of multiple other studies. HPV-positive LSCC trended with higher histologic grade. P16 and cyclin E immunohistochemical stains were of limited use in identifying HPV in LSCC. In contrast, cyclin B had a high sensitivity which could be used to rule out HPV in LSCC.

Indexed as

AdultAgedFemaleHumansLaryngeal NeoplasmsMaleMiddle AgedPapillomaviridaePapillomavirus InfectionsPrevalenceSexually Transmitted Diseases, ViralSquamous Cell Carcinoma of Head and NeckCyclin BCyclin-dependent kinase inhibitor p16Cyclin EHuman papilloma virusLaryngeal squamous cell carcinomaPCR

Identifiers

PMID32146710
PMCPMC7669925
OpenAlexW3009564045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.