Evidence map›Paper›PMID 32146555›Full record

ReviewRadiation and environmental biophysics2020

Individual response of humans to ionising radiation: governing factors and importance for radiological protection.

K E Applegate, W Rühm, A Wojcik, M Bourguignon, A Brenner, K Hamasaki, T Imai, M Imaizumi, T Imaoka, S Kakinuma and 10 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Radiation and environmental biophysics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
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  6. Article
  7. Review
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  12. Review
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  14. Areas of research to support the system of radiological protection.Radiation and environmental biophysics · 2021
    Review
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

K E Applegate, Zionsville, USA. keapple5123@gmail.com.
W RühmHelmholtz Center Munich, German Research Center for Environmental Health, Institute of Radiation Medicine, Neuherberg, Germany.
A WojcikCentre for Radiation Protection Research, MBW Department, Stockholm University, Stockholm, Sweden.
M BourguignonDepartment of Biophysics and Nuclear Medicine, University of Paris Saclay (UVSQ), Verseilles, France.
A BrennerDepartment of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.
K HamasakiDepartment of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
T ImaiNational Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
M ImaizumiDepartment of Nagasaki Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan.
T ImaokaDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
S KakinumaDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
T KamadaQST Hospital, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
N NishimuraDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
N OkonogiQST Hospital, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
K OzasaDepartment of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.
C E RübeDepartment of Radiation Oncology, Saarland University Medical Center, Homburg/Saar, Germany.
A SadakaneDepartment of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.
R SakataDepartment of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.
Y ShimadaNational Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
K YoshidaImmunology Laboratory, Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
S BoufflerRadiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilto, Didcot, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue reactions and stochastic effects after exposure to ionising radiation are variable between individuals but the factors and mechanisms governing individual responses are not well understood. Individual responses can be measured at different levels of biological organization and using different endpoints following varying doses of radiation, including: cancers, non-cancer diseases and mortality in the whole organism; normal tissue reactions after exposures; and, cellular endpoints such as chromosomal damage and molecular alterations. There is no doubt that many factors influence the responses of people to radiation to different degrees. In addition to the obvious general factors of radiation quality, dose, dose rate and the tissue (sub)volume irradiated, recognized and potential determining factors include age, sex, life style (e.g., smoking, diet, possibly body mass index), environmental factors, genetics and epigenetics, stochastic distribution of cellular events, and systemic comorbidities such as diabetes or viral infections. Genetic factors are commonly thought to be a substantial contributor to individual response to radiation. Apart from a small number of rare monogenic diseases such as ataxia telangiectasia, the inheritance of an abnormally responsive phenotype among a population of healthy individuals does not follow a classical Mendelian inheritance pattern. Rather it is considered to be a multi-factorial, complex trait.

Indexed as

Radiation, IonizingAnimalsHumansNeoplasms, Radiation-InducedRadiation ProtectionRadiation ToleranceAnimal modelsCancerepigeneticsGeneticsICRPIndividual variationModifiable risk factorsRadiation riskRadiation sensitivityTissue reactions

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.