Evidence map›Paper›PMID 32146518›Full record

ArticleCancer immunology, immunotherapy : CII2020

Adenosine-producing regulatory B cells in head and neck cancer.

Sandra S Jeske, Matthias Brand, Andreas Ziebart, Simon Laban, Johannes Doescher, Jens Greve, Edwin K Jackson, Thomas K Hoffmann, Cornelia Brunner, Patrick J Schuler

Open access · hybridAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  5. Metabolic Cross Talk in the Tumor Microenvironment.Cancer treatment and research · 2026
    Review
  6. Article
  7. Review
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  10. Article
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  12. Review
  13. Article
  14. Review
  15. Article
  16. Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  17. Nociceptive adenosine AInternational journal of oral science · 2024
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sandra S JeskeDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
Matthias BrandDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
Andreas ZiebartDepartment of Neurosurgery, Mannheim University Medical Center, Mannheim, Germany.
Simon LabanDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
Johannes DoescherDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
Jens GreveDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Thomas K HoffmannDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
Cornelia BrunnerDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
Patrick J SchulerDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany. patrick.schuler@uniklinik-ulm.de.
Universität Ulm · DEUniversity Hospital Heidelberg · DEUniversity of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Deutsche Forschungsgemeinschaft SCHU 2536/3NIDDK NIH HHS P30 DK079307
6 · The paper itself

Abstract

backgroundMultiple mechanisms of immunosuppression have been identified in the tumor microenvironment including regulatory B cells (B

methodsBlood (n = 42) and tumor tissue (n = 39) of head and neck cancer patients and healthy donors (n = 60) were analyzed by FACS. The effect of ADO on phenotype, intracellular signaling pathways, Ca

resultsADO-producing B

conclusionOur data demonstrate the presence of a novel ADO-producing B

Indexed as

AdenineAdenosineAgammaglobulinaemia Tyrosine KinaseAnimalsApoptosisB-Lymphocytes, RegulatoryCase-Control StudiesCell ProliferationHead and Neck NeoplasmsHumansMaleMicePiperidinesPrognosisPyrazolesPyrimidinesAdenineAdenosineAgammaglobulinaemia Tyrosine KinaseBTK protein, humanibrutinibPiperidinesPyrazolesPyrimidinesAdenosineADORA2ABTKHead and neck cancerRegulatory B cells

Identifiers

PMID32146518
PMCPMC7303082
OpenAlexW3010311215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.