ReviewAnalytical and bioanalytical chemistry2020
A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing.
Review in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 109 citations in OpenAlex.
- Raman-guided sample subset selection for cost-efficient offline calibration in bioprocesses.Bioprocess and biosystems engineering · 2026Article
- Applying Raman Spectroscopy for Real-Time Monitoring of Ultra- and Diafiltration Steps in Viral Vector Purification.Pharmaceutics · 2026Article
- Spectroscopy-Based Cell Culture Predictive Monitoring.Biotech (Basel (Switzerland)) · 2026Article
- A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies.Biotechnology and bioengineering · 2026Review
- Hyperspectral image and chemometrics. A step beyond classical spectroscopic PAT tools.Analytical and bioanalytical chemistry · 2026Review
- The Missing Link: Connecting Cultivation Conditions and Refolding Performance via Inclusion Body Biophysical Properties.Biotechnology and bioengineering · 2025Article
- A Novel Raman-Chromatography Assembly for Automated Calibration and In-Line Monitoring in Bioprocessing.Engineering in life sciences · 2025Article
- Current PAT Landscape in the Downstream Processing of Biopharmaceuticals.Analytical science advances · 2025Review
- Accelerating Plasmonic Hydrogen Sensors for Inert Gas Environments by Transformer-Based Deep Learning.ACS sensors · 2025Article
- Raman-based PAT for multi-attribute monitoring during VLP recovery by dual-stage CFF: attribute-specific spectral preprocessing for model transfer.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- Rapid measurement of soluble xylo-oligomers using near-infrared spectroscopy (NIRS) and multivariate statistics: calibration model development and practical approaches to model optimization.Biotechnology for biofuels and bioproducts · 2024Article
- PCA and PLS Analysis of Lanthanides Using Absorbance and Single-Beam Visible Spectra.ACS omega · 2024Article
- Generative data augmentation and automated optimization of convolutional neural networks for process monitoring.Frontiers in bioengineering and biotechnology · 2024Article
- Micro simulated moving bed chromatography-mass spectrometry as a continuous on-line process analytical tool.Analytical and bioanalytical chemistry · 2024Article
- Validation of the cell culture monitoring using a Raman spectroscopy calibration model developed with artificially mixed samples and investigation of model learning methods using initial batch data.Analytical and bioanalytical chemistry · 2024Article
- Data Augmentation Techniques for Machine Learning Applied to Optical Spectroscopy Datasets in Agrifood Applications: A Comprehensive Review.Sensors (Basel, Switzerland) · 2023Review
- Characterisation of Cartilage Damage via Fusing Mid-Infrared, Near-Infrared, and Raman Spectroscopic Data.Journal of personalized medicine · 2023Article
- Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media.Applied spectroscopy · 2023Article
- Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements.Analytical and bioanalytical chemistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and address the recent innovations and applications of spectroscopic methods as PAT tools in the downstream processing of biologics. As data analysis strategies are a crucial part of PAT, the review discusses frequently used data analysis techniques and addresses data fusion methodologies as the combination of several sensors is moving forward in the field. The last chapter will give an outlook on the application of spectroscopic methods in combination with chemometrics and model predictive control (MPC) for downstream processes. Graphical abstract.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.