Evidence map›Paper›PMID 32146494›Full record

ArticleApplied microbiology and biotechnology2020

Bacillus coagulans SANK 70258 suppresses Enterobacteriaceae in the microbiota of ulcerative colitis in vitro and enhances butyrogenesis in healthy microbiota.

Kengo Sasaki, Daisuke Sasaki, Jun Inoue, Namiko Hoshi, Takayuki Maeda, Ryouichi Yamada, Akihiko Kondo

Abstract read
PubMed Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Frontiers in immunology · 2024
    Trial
  3. TargetedFrontiers in microbiology · 2026
    Article
  4. Article
  5. Article
  6. Secondary Metabolites fromCurrent research in microbial sciences · 2025
    Review
  7. American journal of ophthalmology case reports · 2024
    Article
  8. Anticancer Effects ofLife (Basel, Switzerland) · 2024
    Article
  9. Progress of research and application ofFrontiers in cellular and infection microbiology · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. The Effect of Supplementation withVeterinary sciences · 2022
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kengo SasakiGraduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8501, Japan. sikengo@people.kobe-u.ac.jp.
Daisuke SasakiGraduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
Jun InoueDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Namiko HoshiDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Takayuki MaedaBiotechnology Laboratory, Science Innovation Center, Mitsubishi Chemical Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, 227-8502, Japan.
Ryouichi YamadaResearch and Development Center, Mitsubishi-Chemical Foods Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, 227-8502, Japan.
Akihiko KondoGraduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8501, Japan.

Funding

Japan Society for the Promotion of Science 17K12897Japan Society for the Promotion of Science 18K05487
6 · The paper itself

Abstract

The aim of this study was to clarify the effect of the spore-forming and lactic acid-producing probiotic strain, Bacillus coagulans SANK 70258, on human colonic microbiota of healthy subjects and ulcerative colitis patients. A model culture system was employed to construct the in vitro human colonic microbiota, to retain the bacterial species richness and simulate the patient's disordered composition, from the fecal inoculum. Bacterial 16S rRNA gene sequencing confirmed that administration of B. coagulans SANK 70258 (at an initial concentration of 4 × 10

Indexed as

Gastrointestinal MicrobiomeAdultAgedBacillus coagulansButyratesColitis, UlcerativeEnterobacteriaceaeFecesFemaleHealthy VolunteersHumansMaleMiddle AgedProbioticsButyratesBacillus coagulansMicrobiotaProbioticsUlcerative colitis

Identifiers

PMID32146494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.