Evidence map›Paper›PMID 32145934›Full record

ArticleNeuropeptides2020

Neuropeptide Y tonically inhibits an NMDAR➔AC1➔TRPA1/TRPV1 mechanism of the affective dimension of chronic neuropathic pain.

Weisi Fu, Caitlin R Wessel, Bradley K Taylor

Open access · greenAbstract read
In one paragraph

Article in Neuropeptides, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Action potential-independent spontaneous microdomain CaProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Weisi FuDepartment of Physiology, University of Kentucky Medical Center, Lexington, KY, USA.
Caitlin R WesselDepartment of Physiology, University of Kentucky Medical Center, Lexington, KY, USA.
Bradley K TaylorDepartment of Physiology, University of Kentucky Medical Center, Lexington, KY, USA; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Project to end Opioid Misuse, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: bkt@pitt.edu.
University of Kentucky · USUniversity of Pittsburgh · US

Funding

NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSIONR01NS045954 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRADLEY K. TAYLOR · 2002 to 2026
$7.4M
PPAR Inhibition of Spinal Pain TransmissionR01NS062306 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAYLOR, BRADLEY K. · 2009 to 2021
$4.0M
Long-term activation of spinal opioid analgesia after inflammationR01DA037621 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAYLOR, BRADLEY K. · 2015 to 2019
$3.4M
NIDA NIH HHS R01 DA037621NINDS NIH HHS R01 NS045954NINDS NIH HHS R01 NS062306
6 · The paper itself

Abstract

Transection of the sural and common peroneal branches of the sciatic nerve produces cutaneous hypersensitivity at the tibial innervation territory of the mouse hindpaw that resolves within a few weeks. We report that interruption of endogenous neuropeptide Y (NPY) signaling during remission, with either conditional NPY knockdown in NPY

Indexed as

Adenylyl CyclasesAnalgesicsAnimalsHyperalgesiaMaleMiceNeuralgiaNeuropeptide YNociceptionPainPeripheral Nerve InjuriesPosterior Horn CellsReceptors, Neuropeptide YReceptors, N-Methyl-D-AspartateAdenylyl CyclasesAnalgesicsNeuropeptide YReceptors, Neuropeptide YReceptors, N-Methyl-D-Aspartate

Identifiers

PMID32145934
PMCPMC7456540
OpenAlexW3002227003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.