ArticleNeuroImage. Clinical2020
Tracking the neurodegenerative gradient after spinal cord injury.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury.Nature communications · 2026Trial
- Cervical Atrophy Following Complete Thoracic Spinal Cord Injury: Insights From a Multinational Cohort.European journal of neurology · 2026Article
- Brain Morphology in Subacute Spinal Cord Injury: Insights Into Functional Recovery Across Brain Networks.Brain and behavior · 2026Article
- Neuronal plasticity during motor rehabilitation training after spinal cord injury.Communications biology · 2026Article
- Ccn1 Mediates Pyroptosis and Purine Metabolism Pattern Shifts in a High-Uric Acid Microenvironment After Spinal Cord Injury.Molecular neurobiology · 2025Article
- 3D MRI Tract-Specific Spinal Cord Lesion Pattern Improves Prediction of Distinct Neurological Recovery.Annals of clinical and translational neurology · 2025Article
- Using diffusion tensor imaging to assess children with spinal cord injury without fracture or dislocation.Spinal cord · 2025Article
- Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In-VivoJournal of neuroscience research · 2025Article
- SynSpine: an automated workflow for the generation of longitudinal spinal cord synthetic MRI data.Frontiers in neuroinformatics · 2025Article
- The relationship between the structural changes in the cervical spinal cord and sensorimotor function of children with thoracolumbar spinal cord injury (TLSCI).Spinal cord · 2024Article
- Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury.Neuroscience letters · 2024Article
- Optimization of cervical cord synthetic TImaging neuroscience (Cambridge, Mass.) · 2024Article
- Spinal cord injury: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- Magnetic resonance spectroscopy investigation in the right human hippocampus following spinal cord injury.Frontiers in neurology · 2023Article
- Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy.Frontiers in neuroscience · 2023Article
- Impact of injury duration on a sensorimotor functional network in complete spinal cord injury.Journal of neuroscience research · 2022Article
- Degeneration of the Sensorimotor Tract in Degenerative Cervical Myelopathy and Compensatory Structural Changes in the Brain.Frontiers in aging neuroscience · 2022Article
- A Time-Course Study of the Expression Level of Synaptic Plasticity-Associated Genes in Un-Lesioned Spinal Cord and Brain Areas in a Rat Model of Spinal Cord Injury: A Bioinformatic Approach.International journal of molecular sciences · 2021Article
- Improving Diagnostic Workup Following Traumatic Spinal Cord Injury: Advances in Biomarkers.Current neurology and neuroscience reports · 2021Review
- Microstructural plasticity in nociceptive pathways after spinal cord injury.Journal of neurology, neurosurgery, and psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo quantify neurodegenerative changes along the cervical spinal cord rostral to a spinal cord injury (SCI) by means of quantitative MRI (qMRI) and to determine its relationship with clinical impairment.
methodsThirty chronic SCI patients (15 tetraplegics and 15 paraplegics) and 23 healthy controls underwent a high-resolution T1-weighted and myelin-sensitive magnetization transfer (MT) MRI. We assessed macro- and microstructural changes along the cervical cord from levels C1 to C4, calculating cross-sectional spinal cord area, its anterior-posterior and left-right width and myelin content (i.e. MT). Regression analysis determined associations between qMRI parameters and clinical impairment.
resultsIn SCI patients, cord area decreased by 2.67 mm
conclusionsA gradient of neurodegeneration is evident in the cervical cord remote from a SCI. Tract-specific associations with appropriate clinical outcomes highlight that remote neurodegenerative changes are clinically eloquent. Monitoring the neurodegenerative gradient could be used to track treatment effects of regenerative and neuroprotective agents, both in trials targeting cervical and thoracic SCI patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.