ArticleInternational journal of surgery case reports2020
Adult H3K27M-mutant diffuse midline glioma with gliomatosis cerebri growth pattern: Case report and review of the literature.
Article in International journal of surgery case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Prevalence and Clinicoradiopathological Characterization of H3 K27-Altered Diffuse Midline Gliomas in Adults-A Retrospective Observational Study.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Adult Medullary Diffuse Midline Glioma Presenting with Orthostatic Hypotension: A Case Report.NMC case report journal · 2026Article
- Diffuse midline glioma, H3K27-altered: a rare presentation with gliomatosis cerebri growth pattern and progression toward midline.Brain tumor pathology · 2026Article
- Article
- Clinico-Pathological Features of Diffuse Midline Glioma, H3 K27-Altered in Adults: A Comprehensive Review of the Literature with an Additional Single-Institution Case Series.Diagnostics (Basel, Switzerland) · 2024Article
- Fulminant hemorrhagic course of a thalamic H3 K27-altered diffuse midline glioma in an adult patient: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Adult-type and Pediatric-type Diffuse Gliomas : What the Neuroradiologist Should Know.Clinical neuroradiology · 2023Review
- A validated prognostic nomogram for patients with H3 K27M-mutant diffuse midline glioma.Scientific reports · 2023Article
- The clinicopathological features and prognosis of multifocal high-grade gliomas in adults withNeurosciences (Riyadh, Saudi Arabia) · 2023Article
- A curious case of T2-FLAIR mismatch in H3K27M mutant glioma.Radiology case reports · 2022Article
- The 2021 World Health Organization Classification of Tumors of the Central Nervous System: What Neuroradiologists Need to Know.AJNR. American journal of neuroradiology · 2022Review
- Diffuse midline glioma H3K27M mutation in adult: A case report.Annals of medicine and surgery (2012) · 2022Article
- Panobinostat in adults with H3 K27M-mutant diffuse midline glioma: a single-center experience.Journal of neuro-oncology · 2022Article
- Cerebellar high-grade glioma with H3 K27M mutation: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- The many faces of glioblastoma: Pictorial review of atypical imaging features.The neuroradiology journal · 2021Review
- Genomic Profiling Identified Novel Prognostic Biomarkers in Chinese Midline Glioma Patients.Frontiers in oncology · 2020Article
- Bone metastases in an adult patient with diffuse midline glioma: a case report.Neuro-oncology advancesArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionH3K27M-mutant diffuse midline glioma is a recently classified unique entity predominantly affecting pediatric patients and rarely adults. The clinicopathologic features in adults remain poorly characterized. PRESENTATION OF CASE: A 36-year-old man presented with subacute progressive cognitive and visual deterioration, and hydrocephalus requiring ventricular shunting. MRI revealed a diffusely infiltrating lesion with a gliomatosis cerebri growth pattern, multiple foci of contrast enhancement, and diffuse leptomeningeal involvement. Suboccipital craniotomy with exploration of the posterior fossa revealed a subtle capsular lesion infiltrating into the choroid plexus. Although histologically low-grade, the tumor was found to have an H3K27 M mutation establishing the diagnosis. DISCUSSION: In spite of diverse clinicopathologic characteristics, H3K27M-mutant diffuse midline gliomas are incurable, WHO grade IV lesions with poor prognosis. We discuss our case in the context of a review of published reports of H3K27-mutant diffuse midline gliomas in adults. Findings late in the disease course may mimic inflammatory or infectious pathologies radiographically, and low-grade infiltrative neoplasms histologically.
conclusionThe diverse clinical, radiographic and molecular features of H3K27M-mutant diffuse midline gliomas in adults remain to be completely characterized. A high index of suspicion is required to avoid missing the diagnosis. Early biopsy and detailed molecular characterization are critical for accurate diagnosis and patient counseling.
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