ArticlePsychiatry research. Neuroimaging2020
Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study.
Article in Psychiatry research. Neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis.Schizophrenia bulletin · 2024Pooled it
- Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography.Molecular psychiatry · 2024Pooled it
- Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Retinal cytoarchitectural alterations across the psychosis spectrum and their correlates with cognition: a UK biobank nested case-control study.Molecular psychiatry · 2026Article
- Severity-dependent fronto-cingulate network compensation of immune-dependent caudate-insula dysconnectivity in bipolar II depression.Research square · 2026Article
- Evaluation of the Electroconvulsive Therapy's Impact on Retinal Structures in First-Episode Psychosis Patients Using Optical Coherence Tomography.Schizophrenia bulletin · 2026Article
- The Retinal Age Gap as a Marker of Accelerated Aging in the Early Course of Schizophrenia.Schizophrenia bulletin · 2026Article
- Retina in Clinical High-Risk and First-Episode Psychosis.Schizophrenia bulletin · 2026Article
- The BAsic NeuroCognitive Continuum (BANCC): Delineation of dimensional and categorical features for etiological and treatment investigations of idiopathic psychosis.Psychiatry and clinical neurosciences · 2025Article
- Epiphenomena in psychosis: how perinatal stressful events shape long-term outcomes.Molecular psychiatry · 2025Review
- Thinning of central foveal thickness in the retina of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Painting psychosis: an empirical investigation of the self-portraits of Edvard Munch.Frontiers in psychiatry · 2025Article
- Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review.Neuropsychobiology · 2025Article
- Retinal biomarkers in schizophrenia spectrum disorders: evidence and implications for the neurodevelopmental and neurodegenerative models.Frontiers in medicine · 2025Review
- Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum.Frontiers in psychiatry · 2025Article
- Evaluation of retinal structure changes with AI-based OCT image segmentation for sodium iodate induced retinal degeneration.Frontiers in cellular neuroscience · 2025Article
- Retinal electrophysiological alterations are associated with cognition in early course psychosis.Schizophrenia research · 2024Article
- Retinal layers and symptoms and inflammation in schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Electroretinographic dysfunction, insulin resistance, and childhood trauma in early-course psychosis: A case-control exploratory study.Biomarkers in neuropsychiatry · 2024Article
- Oculomics: A Crusade Against the Four Horsemen of Chronic Disease.Ophthalmology and therapy · 2024Review
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
Studies utilizing optical coherence tomography (OCT) in psychosis have identified abnormalities in retinal cytoarchitecture. We aim to analyze retinal layer topography in psychosis and its correlation with clinical and imaging parameters. Macular retinal images were obtained via OCT in psychosis probands (n = 25) and healthy controls (HC, n = 15). Clinical, cognitive and structural MRI data were collected from participants. No thinning was noted for the retinal nerve fiber, ganglion cell or inner plexiform layers. We found significant thinning in the right inner temporal, right central, and left inner superior quadrants of the outer nuclear layer (ONL) in probands compared to HC. Thickening of the outer plexiform layer (OPL) was observed in the right inner temporal, left inner superior, and left inner temporal quadrants. The right inner temporal and left inner superior quadrants of both the OPL and ONL showed significant inverse correlations. Retinal pigment epithelium thinning correlated with worse mania symptoms, and thinning in the ONL was associated with worse cognitive function. ONL thinning was also associated with smaller total brain and white matter volume. Our findings suggest that outer retinal layers may provide additional insights into the pathophysiology of psychosis, possibly reflecting synaptic or inflammatory aberrations that lead to retinal pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.