Evidence map›Paper›PMID 32145355›Full record

ReviewFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2020

Neurotoxicity of e-cigarettes.

Joanna A Ruszkiewicz, Ziyan Zhang, Filipe Marques Gonçalves, Yousef Tizabi, Judith T Zelikoff, Michael Aschner

Registry-linked trialAbstract readReview
In one paragraph

Review in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06297005 (The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes), which is not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06297005 recruitingnot on this mapstarted 2023, after this paper: background citation

The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes (ECHO) Study.

TypeobservationalSponsorUniversity College DublinRan2023 to 2027Enrolled1,200ConditionsVaping, Pregnancy Related, Pediatric Respiratory Diseases
3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Article
  3. Vaping-related lung disease: a narrative review.Journal of thoracic disease · 2026
    Review
  4. Article
  5. Human Primary Mesenchymal Stem Cells Fail to Recover Full Osteogenic Differentiation Potential Following Washout of Electronic Cigarette Aerosol Extracts.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  6. The geographic distribution and community correlates of electronic cigarette use in Canada.Canadian journal of public health = Revue canadienne de sante publique · 2026
    Article
  7. Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026
    Review
  8. Editorial Perspective: Smoking, vaping and mental health - a perspective on potential causal mechanisms.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joanna A RuszkiewiczMolecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz, Germany.
Ziyan ZhangDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.
Filipe Marques GonçalvesBiochemistry Graduate Program, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Yousef TizabiDepartment of Pharmacology, Howard University College of Medicine, Washington DC, United States.
Judith T ZelikoffDepartment of Environmental Medicine, New York University School of Medicine, Manhattan, NY, United States.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: michael.aschner@einsteinmed.org.

Funding

Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing BrainR01ES020852 · NIEHS · VANDERBILT UNIVERSITY · PI ASCHNER, MICHAEL · 2012 to 2016
$1.8M
Role of autophagy in manganese-induced neurotoxicityR21ES028960 · NIEHS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ZHANG, ZIYAN · 2018 to 2019
$459k
NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES010563NIEHS NIH HHS R01 ES020852NIEHS NIH HHS R21 ES028960
6 · The paper itself

Abstract

It appears that electronic cigarettes (EC) are a less harmful alternative to conventional cigarette (CC) smoking, as they generate substantially lower levels of harmful carcinogens and other toxic compounds. Thus, switching from CC to EC may be beneficial for smokers. However, recent accounts of EC- or vaping-associated lung injury (EVALI) has raised concerns regarding their adverse health effects. Additionally, the increasing popularity of EC among vulnerable populations, such as adolescents and pregnant women, calls for further EC safety evaluation. In this state-of-the-art review, we provide an update on recent findings regarding the neurological effects induced by EC exposure. Moreover, we discuss possible neurotoxic effects of nicotine and numerous other chemicals which are inherent both to e-liquids and EC aerosols. We conclude that in recognizing pertinent issues associated with EC usage, both government and scientific researchers must address this public health issue with utmost urgency.

Indexed as

Electronic Nicotine Delivery SystemsNeurotoxicity SyndromesAdolescentAerosolsAnimalsBrainFemaleFree RadicalsHumansMetals, HeavyNanoparticlesNicotinePregnancyPublic HealthSmokersSmokingAerosolsFree RadicalsMetals, HeavyNicotineTrace ElementsBraine-cigaretteElectronic cigaretteNeurodevelopmentNeurotoxicityVaping

Identifiers

PMID32145355
PMCPMC7089837

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.