Evidence map›Paper›PMID 32145257›Full record

ArticleJournal of hepatology2020

[

Tuo Shao, Zhen Chen, Vasily Belov, Xiaohong Wang, Steve H Rwema, Viksit Kumar, Hualong Fu, Xiaoyun Deng, Jian Rong, Qingzhen Yu and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
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  7. Non-invasive visualization of liver fibrosis with [European journal of nuclear medicine and molecular imaging · 2024
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  9. Article
  10. Review
  11. Article
  12. A comparison study of dynamic [Journal of cancer research and clinical oncology · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Staging Liver Fibrosis by Fibroblast Activation Protein Inhibitor PET in a Human-Sized Swine Model.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Tuo ShaoDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA; Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, USA.
Zhen ChenDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Vasily BelovMassachusetts General Hospital, Shriners Hospitals for Children, Boston, USA.
Xiaohong WangCenter for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Steve H RwemaLiver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, USA.
Viksit KumarCenter for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Hualong FuDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Xiaoyun DengDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Jian RongDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Qingzhen YuDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Lixin LangLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, USA.
Wenyu LinLiver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, USA.
Lee JosephsonDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Anthony E SamirCenter for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Xiaoyuan ChenLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, USA. Electronic address: shawn.chen@nih.gov.
Raymond T ChungLiver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, USA. Electronic address: rtchung@partners.org.
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA. Electronic address: liang.steven@mgh.harvard.edu.
Massachusetts General Hospital · USNational Institutes of Health · USShriners Hospitals for Children - Boston · US

Funding

Molecular Tracer and Imaging Core FacilityZICEB000087 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI LANG, LIXIN · 2017 to 2025
$11.3M
HIV, HCV, Hippo, and Liver Disease ProgressionR01AI136715 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, RAYMOND T · 2018 to 2022
$3.4M
Mechanism of Action of Novel Subunit-Selective NMDA Receptor ModulatorsR01NS065371 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2009 to 2018
$3.4M
HIV-Associated Macrophage Alterations and Progressive Liver DiseaseR01DK108370 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, RAYMOND T · 2015 to 2019
$1.6M
New PET tracers for neuroimaging of FAAH in endocannabinoid signalingK01DA038000 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2014 to 2018
$927k
NIAID NIH HHS R01 AI136715NIDA NIH HHS K01 DA038000NIDDK NIH HHS R01 DK108370NINDS NIH HHS R01 NS065371
6 · The paper itself

Abstract

BACKGROUND &

aimsThe vitronectin receptor integrin αvβ3 drives fibrogenic activation of hepatic stellate cells (HSCs). Molecular imaging targeting the integrin αvβ3 could provide a non-invasive method for evaluating the expression and the function of the integrin αvβ3 on activated HSCs (aHSCs) in the injured liver. In this study, we sought to compare differences in the uptake of [

methodsPET with [

resultsFibrotic mouse livers showed enhanced [

conclusionsImaging hepatic integrin αvβ3 with PET and [ LAY SUMMARY: Integrin αvβ3 expression on activated hepatic stellate cells (aHSCs) is associated with HSC proliferation during hepatic fibrogenesis. Herein, we show that a radioactive tracer, [

Indexed as

Liver CirrhosisAnimalsDisease ProgressionFluorescent Antibody TechniqueFluorine RadioisotopesGene Expression ProfilingHepatic Stellate CellsIntegrin alphaVbeta3MiceMolecular ImagingPeptides, CyclicPositron-Emission TomographyReproducibility of ResultsSensitivity and Specificityalfatide IIFluorine RadioisotopesIntegrin alphaVbeta3Peptides, Cyclic[(18)F]-AlfatideIntegrin αvβ3Liver fibrosisPET imaging

Identifiers

PMID32145257
PMCPMC7363052
OpenAlexW3009897837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.