Evidence map›Paper›PMID 32145185›Full record

ReviewLancet (London, England)2020

Middle East respiratory syndrome.

Ziad A Memish, Stanley Perlman, Maria D Van Kerkhove, Alimuddin Zumla

Registry-linked trialAbstract readReview
In one paragraph

Review in Lancet (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04550403 (Clinical Phenotype and Outcomes of Inpatients With COVID-19 and Diabetes), which is not on this map. Cited by 250 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04550403 completednot on this map

Clinical Phenotype and Outcomes of Inpatients With COVID-19 and Diabetes

TypeobservationalSponsorAzienda Ospedaliero-Universitaria di ParmaRan2020 to 2021Enrolled757ConditionsDiabetes Mellitus, Covid19
3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Pooled it
  7. Trial
  8. Review
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  18. Review
  19. Scientific Writing- an Editor's Memo to Emerging Authors-1.Journal of epidemiology and global health · 2025
    Article
  20. Epidemiological Characteristics of MERS-CoV Human Cases, 2012- 2025.Journal of epidemiology and global health · 2025
    Article

190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ziad A MemishCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Research Center, King Saud Medical City Ministry of Health, Riyadh, Saudi Arabia; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Stanley PerlmanDepartment of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Maria D Van KerkhoveInfectious Hazards Management, Health Emergencies Programme, World Health Organization, Geneva, Switzerland.
Alimuddin ZumlaDepartment of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, UK; National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, UK. Electronic address: a.zumla@ucl.ac.uk.

Funding

SARS-CoV Proteins in Heterologous Viral InfectionP01AI060699 · NIAID · UNIVERSITY OF IOWA · PI PERLMAN, STANLEY · 2004 to 2021
$21.5M
Role of eicosanoids in pathogenic human CoV infectionsR01AI129269 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 2016 to 2026
$4.7M
NIAID NIH HHS P01 AI060699NIAID NIH HHS R01 AI129269World Health Organization 001
6 · The paper itself

Abstract

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention.

Indexed as

EpidemicsMiddle East Respiratory Syndrome CoronavirusAdrenal Cortex HormonesAdultAnimalsAntibodies, MonoclonalAntiviral AgentsCamelusChildClinical Laboratory TechniquesCoronavirus InfectionsCritical CareCross InfectionFemaleGlobal HealthHumansAdrenal Cortex HormonesAntibodies, MonoclonalAntiviral AgentsViral Vaccines

Identifiers

PMID32145185
PMCPMC7155742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.