ArticleMolecular biology and evolution2020
Limited Evidence for Selection at the FADS Locus in Native American Populations.
Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- SimOutbreakSelection: a simulation-based tool to optimise sampling design and analysis strategies for detecting epidemic-driven selection.Nature communications · 2025Article
- Signatures of natural selection may indicate a genetic basis for the beneficial effects of oily fish intake in indigenous people from coastal Ecuador.G3 (Bethesda, Md.) · 2025Article
- Precision nutrition across climates: decoding diet, tradition, and genomic adaptations from South Asia to the Arctic.Frontiers in nutrition · 2025Review
- An ancient ecospecies of Helicobacter pylori.Nature · 2024Article
- Predicting Functional Consequences of Recent Natural Selection in Britain.Molecular biology and evolution · 2024Article
- Unveiling recent and ongoing adaptive selection in human populations.PLoS biology · 2024Article
- Predicting functional consequences of recent natural selection in Britain.bioRxiv : the preprint server for biology · 2023Article
- Tensor Decomposition-based Feature Extraction and Classification to Detect Natural Selection from Genomic Data.Molecular biology and evolution · 2023Article
- Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe.Cell genomics · 2023Article
- Beringia and the peopling of the Western Hemisphere.Proceedings. Biological sciences · 2023Review
- Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion.Acta paediatrica (Oslo, Norway : 1992) · 2022Review
- Population Genetics and Signatures of Selection in Early Neolithic European Farmers.Molecular biology and evolution · 2022Article
- Disentangling Signatures of Selection Before and After European Colonization in Latin Americans.Molecular biology and evolution · 2022Article
- Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry andFrontiers in nutrition · 2021Review
- Human adaptation over the past 40,000 years.Current opinion in genetics & development · 2020Review
- Inference of natural selection from ancient DNA.Evolution letters · 2020Article
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1 author at 1 institution in 1 country.
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Abstract
The FADS locus contains the genes FADS1 and FADS2 that encode enzymes involved in the synthesis of long-chain polyunsaturated fatty acids. This locus appears to have been a repeated target of selection in human evolution, likely because dietary input of long-chain polyunsaturated fatty acids varied over time depending on environment and subsistence strategy. Several recent studies have identified selection at the FADS locus in Native American populations, interpreted as evidence for adaptation during or subsequent to the passage through Beringia. Here, we show that these signals are confounded by independent selection-postdating the split from Native Americans-in the European and, possibly, the East Asian populations used in the population branch statistic test. This is supported by direct evidence from ancient DNA that one of the putatively selected haplotypes was already common in Northern Eurasia at the time of the separation of Native American ancestors. An explanation for the present-day distribution of the haplotype that is more consistent with the data is that Native Americans retain the ancestral state of Paleolithic Eurasians. Another haplotype at the locus may reflect a secondary selection signal, although its functional impact is unknown.
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