Evidence map›Paper›PMID 32144727›Full record

ArticleJournal of neurovirology2020

Zika virus infection in chemosensory cells.

Mehmet Hakan Ozdener, Martina Donadoni, Stephanie Cicalese, Andrew I Spielman, Alvaro Garcia-Blanco, Jennifer Gordon, Ilker Kudret Sariyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Coronavirus infection in chemosensory cells.Journal of neurovirology · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mehmet Hakan OzdenerMonell Chemical Senses Center, Philadelphia, PA, 19104, USA. hozdener@monell.org.
Martina DonadoniDepartment of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA.
Stephanie CicaleseDepartment of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA.
Andrew I SpielmanNew York University College of Dentistry, New York, NY, 10010, USA.
Alvaro Garcia-BlancoMonell Chemical Senses Center, Philadelphia, PA, 19104, USA.
Jennifer GordonDepartment of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA.
Ilker Kudret SariyerDepartment of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Medical Education and Research Building, 7th Floor, Philadelphia, PA, 19140, USA. isariyer@temple.edu.ORCID 0000-0002-0641-6141
Temple University · USMonell Chemical Senses Center · USNew York University · US

Funding

Viral Gene Editing and Bioinformatics Core for Institution # 269291P30MH092177 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Kamel Khalili · 2011 to 2026
$24.9M
Molecular BiologyP30DC011735 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI REED, DANIELLE RENEE · 2011 to 2015
$2.5M
NIDCD NIH HHS P30 DC011735NIMH NIH HHS P30 MH092177
6 · The paper itself

Abstract

Zika virus (ZIKV) is an emerging virus belonging to the genus Flavivirus. ZIKV infection is a significant health concern, with increasing numbers of reports of microcephaly cases in fetuses and Guillain-Barré syndrome (GBS) in adults. Interestingly, chemosensory disturbances are also reported as one of the manifestations of GBS. ZIKV infects several human tissues and cell types in vitro and in vivo. However, there is no study demonstrating ZIKV infection and replication in chemosensory cells, including olfactory and taste cells. Taste papilla and olfactory cells are chemosensory receptor cells with unique histological, molecular, and physiological characteristics. Here we examined ZIKV infection (PRVABC59) in cultured human olfactory epithelial cells (hOECs) and fungiform taste papilla (HBO) cells in vitro, as well as in vivo mouse taste and olfactory epithelial and olfactory bulb tissues. Interestingly, while HBO cells showed resistance to ZIKV replication, hOECs were highly susceptible for ZIKV infection and replication. Further, we demonstrated the presence of ZIKV particles and expression of viral proteins in olfactory epithelium, as well as in olfactory bulb, but not in taste papillae, of immunocompromised mice (ifnar

Indexed as

AnimalsCell LineChemoreceptor CellsFemaleGene ExpressionHost-Pathogen InteractionsHumansMaleMiceMice, KnockoutOrgan SpecificityReceptor, Interferon alpha-betaSmellTasteVirus ReplicationZika VirusIfnar1 protein, mouseReceptor, Interferon alpha-betaCentral nervous systemChemosensoryInfectionOlfactory cellsTaste cellsZika virus (ZIKV)

Identifiers

PMID32144727
PMCPMC7332368
OpenAlexW3009638527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.