Evidence map›Paper›PMID 32144606›Full record

ArticleJournal of autism and developmental disorders2020

Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder.

Yan Li, Shuang Qiu, Weijing Zhong, Yong Li, Yunkai Liu, Yi Cheng, Yawen Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Oral Health and Autism Spectrum Disorders: A Unique Collaboration between Dentistry and Occupational Therapy.International journal of environmental research and public health · 2020
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yan LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Shuang QiuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Weijing ZhongChunguang Rehabilitation Hospital, Changchun, 130021, China.
Yong LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Yunkai LiuInstitute of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Yi ChengInstitute of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China. chengyi@jlu.edu.cn.
Yawen LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China. ywliu@jlu.edu.cn.
Jilin University · CNChangchun 208 Hospital · CNFirst Hospital of Jilin University · CN

Funding

China Postdoctoral Science Foundation 2013M530989Jilin Provincial Key Laboratory of Neuronal Plasticity 20140622001JCJilin Provincial Key Laboratory of Neuronal Plasticity 20160622020JCNatural Science Foundation of China 81573230Science and Technology Department of Jilin Province 20150101130JCthe Ministry of Science and Technology of the People's Republic of China 2015DFA31580
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD.

Indexed as

AdolescentAsian PeopleAutism Spectrum DisorderCase-Control StudiesChildChild, PreschoolDCC ReceptorFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansMalePolymorphism, Single NucleotideDCC protein, humanDCC ReceptorAutism spectrum disorderDeleted in colorectal carcinoma geneHaplotype analysisSingle nucleotide polymorphismsSusceptibility

Identifiers

PMID32144606
OpenAlexW3009578846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.