Evidence map›Paper›PMID 32144553›Full record

ArticleMolecular biotechnology2020

Adenovirus Biodistribution is Modified in Sensitive Animals Compared to Naïve Animals.

Ana Sandoval-Rodríguez, Mayra Mena-Enriquez, Jesús García-Bañuelos, Adriana Salazar-Montes, Mary Fafutis-Morris, Monica Vázquez-Del Mercado, Arturo Santos-García, Juan Armendariz-Borunda

Abstract read
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In one paragraph

Article in Molecular biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ana Sandoval-RodríguezDepartment of Molecular Biology and Genomics, Institute for Molecular Biology and Gene Therapy, University of Guadalajara, Sierra Mojada 950, Colonia Independencia, Edificio Q. Tercer Piso, CP 44340, Guadalajara, Jalisco, Mexico.
Mayra Mena-EnriquezDepartment of Health Sciences, University of Guadalajara, Av. Periférico Oriente 555, Ejido San José Tateposco, CP 48525, Tonalá, Jalisco, Mexico.
Jesús García-BañuelosDepartment of Molecular Biology and Genomics, Institute for Molecular Biology and Gene Therapy, University of Guadalajara, Sierra Mojada 950, Colonia Independencia, Edificio Q. Tercer Piso, CP 44340, Guadalajara, Jalisco, Mexico.
Adriana Salazar-MontesDepartment of Molecular Biology and Genomics, Institute for Molecular Biology and Gene Therapy, University of Guadalajara, Sierra Mojada 950, Colonia Independencia, Edificio Q. Tercer Piso, CP 44340, Guadalajara, Jalisco, Mexico.
Mary Fafutis-MorrisDepartment of Physiology, Research Center for Immunology and Dermatology, University of Guadalajara, Av Federalismo Norte 3102, Atemajac del Valle, 45190, Zapopan, Jalisco, Mexico.
Monica Vázquez-Del MercadoIIRSME, CUCS, University of Guadalajara, Guadalajara, Mexico.
Arturo Santos-GarcíaTecnologico de Monterrey, Campus Guadalajara, Guadalajara, Jalisco, Mexico.
Juan Armendariz-BorundaDepartment of Molecular Biology and Genomics, Institute for Molecular Biology and Gene Therapy, University of Guadalajara, Sierra Mojada 950, Colonia Independencia, Edificio Q. Tercer Piso, CP 44340, Guadalajara, Jalisco, Mexico. armdbo@gmail.com.
Universidad de Guadalajara · MXTecnológico de Monterrey · MX

Funding

Consejo Nacional de Ciencia y Tecnología 103772Consejo Nacional de Ciencia y Tecnología 259096
6 · The paper itself

Abstract

Pre-existing immune response against adenovirus could diminish transgene expression efficiency when Ad is employed in humans as gene therapy vector. We previously used Ad-hΔuPA (Recombinant adenovirus expressing human urokinase-type plasminogen activator) as antifibrotic gene therapy in cirrhosis models and demonstrated its effectiveness. As a further clinical approach, transient Cyclosporine A (CsA) immunosuppression was induced in cirrhotic animals to determine whether Ad-hΔuPA administration retained efficacy. Adenovirus sensitization was achieved by systemic administration of non-therapeutic Ad-βGal (Recombinant adenovirus expressing beta-galactosidase) after 4 weeks of intraperitoneal carbon tetrachloride (CCl

Indexed as

AdenoviridaeAnimalsCarbon TetrachlorideCyclosporineGenetic TherapyImmunizationImmunosuppressive AgentsLiver CirrhosisRatsTissue DistributionTransgenesUrokinase-Type Plasminogen ActivatorCarbon TetrachlorideCyclosporineImmunosuppressive AgentsUrokinase-Type Plasminogen ActivatorAdenovirusCirrhosisCyclosporineFibrosisLiverSensitizationTransient immunosuppressionuPA

Identifiers

PMID32144553
OpenAlexW3009777157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.