Evidence map›Paper›PMID 32144523›Full record

ArticleFish physiology and biochemistry2020

Impaired peroxisomal fat oxidation induces hepatic lipid accumulation and oxidative damage in Nile tilapia.

Yan Liu, Si-Lan Han, Yuan Luo, Ling-Yu Li, Li-Qiao Chen, Mei-Ling Zhang, Zhen-Yu Du

Abstract read
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In one paragraph

Article in Fish physiology and biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yan LiuLANEH, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Si-Lan HanLANEH, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Yuan LuoLANEH, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Ling-Yu LiLANEH, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Li-Qiao ChenLANEH, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Mei-Ling ZhangLANEH, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Zhen-Yu DuLANEH, School of Life Sciences, East China Normal University, Shanghai, 200241, China. zydu@bio.ecnu.edu.cn.
East China Normal University · CN

Funding

National Natural Science Foundation of China 31830102Program of Shanghai Academic Research Leader 19XD1421200
6 · The paper itself

Abstract

Many metabolic diseases in fish are often associated with lowered peroxisomal fatty acid (FA) β-oxidation. However, the physiological role of peroxisomal FA oxidation in lipid metabolism in fish still remains unclear. In the present study, a specific peroxisomal FA β-oxidation inhibitor, 10,12-tricosadiynoic acid (TDYA), was used to investigate the effects of impaired peroxisomal β-oxidation on growth performance, health status, and lipid metabolism in Nile tilapia. The results showed that the dietary TDYA treatment did not affect weight gain, but significantly decreased peroxisomal β-oxidation in the liver, and increased body fat accumulation. The fish with impaired peroxisomal β-oxidation exhibited higher contents of serum lipid and peroxidation products, and alanine aminotransferase activity, and significantly lowered hepatic activities of superoxide dismutase and catalase. The inhibited peroxisomal β-oxidation did not enhance mitochondrial β-oxidation activity, but compensatorily upregulated FA β-oxidation-related gene expression, and downregulated the gene expressions in lipolysis and lipogenesis. Taken together, TDYA treatment markedly induced lipid accumulation and hepatic oxidative damage via systemically depressing lipid catabolism and antioxidant capacity. Our findings reveal the pivotal roles of peroxisomal β-oxidation in maintaining health and lipid homeostasis in fish, and could be helpful in understanding metabolic diseases in fish.

Indexed as

Analysis of VarianceAnimalsBody WeightCichlidsDietDietary FatsFatty AcidsGene ExpressionLipid MetabolismLiverOxidation-ReductionPeroxisomesRandom AllocationSoybean OilDietary FatsFatty AcidsSoybean OilLipid accumulationLipid metabolismNile tilapiaOxidative damagePeroxisomal fatty acid β-oxidation

Identifiers

PMID32144523
OpenAlexW3010053669

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.