Evidence map›Paper›PMID 32144521›Full record

ReviewInflammopharmacology2020

Selenium and selenoproteins: it's role in regulation of inflammation.

Sneha Hariharan, Selvakumar Dharmaraj

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Inflammopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05648422 (Effect of the Nutritional Support System), which is not on this map. Cited by 304 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
304citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05648422 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of the Nutritional Support System (NSS) on Neuromotor Alterations in Patients With Cerebral Palsy

TypeinterventionalSponsorAnahuac UniversityRan2023 to 2025Enrolled144ConditionsCerebral Palsy, Spastic, MalnutritionArmsProbiotics, NSS Nutritional Support System, Deworming, Specific diet, Conventional diet (WHO)
3 · Its place in the literature

Who cites it

304 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Wound Healing Potential of Selenium and Nanoselenium.Biological trace element research · 2026
    Review
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244 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sneha HariharanDepartment of Biochemistry, Karpagam Academy of Higher Education, Eachanari Post, Pollachi Main Road, Coimbatore, Tamil Nadu, 641021, India.
Selvakumar DharmarajDepartment of Biochemistry, Karpagam Academy of Higher Education, Eachanari Post, Pollachi Main Road, Coimbatore, Tamil Nadu, 641021, India. biochem_selva@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium is an essential immunonutrient which holds the human's metabolic activity with its chemical bonds. The organic forms of selenium naturally present in human body are selenocysteine and selenoproteins. These forms have a unique way of synthesis and translational coding. Selenoproteins act as antioxidant warriors for thyroid regulation, male-fertility enhancement, and anti-inflammatory actions. They also participate indirectly in the mechanism of wound healing as oxidative stress reducers. Glutathione peroxidase (GPX) is the major selenoprotein present in the human body, which assists in the control of excessive production of free radical at the site of inflammation. Other than GPX, other selenoproteins include selenoprotein-S that regulates the inflammatory cytokines and selenoprotein-P that serves as an inducer of homeostasis. Previously, reports were mainly focused on the cellular and molecular mechanism of wound healing with reference to various animal models and cell lines. In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail. Some of the selenium containing compounds which can acts as cancer preventive and therapeutics are also discussed. These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage. Although the review covers the importance of selenium/selenoproteins in wound healing process, still some unresolved mystery persists which may be resolved in near future.

Indexed as

AnimalsAntioxidantsHumansInflammationOxidation-ReductionReactive Oxygen SpeciesSeleniumSelenoproteinsAntioxidantsReactive Oxygen SpeciesSeleniumSelenoproteinsGpxsROSSeleniumSelenium drugsSelenoproteinsSEPP1SEPS1Wound healing

Identifiers

PMID32144521
PMCPMC7222958

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.