Trial reportClinical research in cardiology : official journal of the German Cardiac Society2020
Spot urinary sodium in acute decompensation of advanced heart failure and dilutional hyponatremia: insights from DRAIN trial.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The value of urinary sodium assessment in acute heart failure.European heart journal. Acute cardiovascular care · 2021Pooled it
- Elevated urinary sodium thresholds in high-salt diet heart failure: implications for diuretic resistance diagnosis.Frontiers in cardiovascular medicine · 2026Article
- Review
- Spot urinary sodium as a prognostic marker for mortality in patients with acute decompensated heart failureBiomedica : revista del Instituto Nacional de Salud · 2023Article
- The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study.Life (Basel, Switzerland) · 2023Article
- Spot Urinary Sodium Measurements: the Future Direction of the Treatment and Follow-up of Patients with Heart Failure.Current heart failure reports · 2023Review
- Urine biochemistry assessment in the sequential evaluation of renal function: Time to think outside the box.Frontiers in medicine · 2022Article
- Renoprotection by long-term low-dose tolvaptan in patients with heart failure and hyponatremia.ESC heart failure · 2021Article
- Rationale and Design of the Efficacy of a Standardized Diuretic Protocol in Acute Heart Failure Study.ESC heart failure · 2021Article
- Intensification of pharmacological decongestion but not the actual daily loop diuretic dose predicts worse chronic heart failure outcome: insights from TIME-CHF.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Urinary sodium evaluation: the missing target for diuretic treatment optimization in acute heart failure patients? Reply.European journal of heart failure · 2020Article
- Patient Selection and End Point Definitions for Decongestion Studies in Acute Decompensated Heart Failure: Part 1.Journal of the Society for Cardiovascular Angiography & InterventionsReview
- Urine sodium concentration after intravenous furosemide in dogs with acute congestive heart failure and correlation with treatment efficacy.Journal of veterinary internal medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiuretic resistance portends a poor prognosis in acute heart failure, especially in advanced stages. Early identification of a poor response to diuretics may help to improve treatment and outcomes. Spot natriuresis (UNa METHODS AND
resultsWe performed a sub-analysis of the DRAIN trial, a randomized clinical trial on 80 patients with acute decompensation of ACHF (NYHA IV, EF ≤ 30%) with low systolic blood pressure (≤ 110 mmHg) and dilutional hyponatremia (sodium ≤ 135 mMol/L) at admission. Patients were divided into two groups according to spot urinary sodium excretion (high: UNa
conclusionsIn patients with ACHF and dilutional hyponatremia, low natriuresis after furosemide is an early marker of poor diuretic response and correlates with higher NT-proBNP and higher incidence of worsening renal function at 72 h.
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