ArticleAnalytical and bioanalytical chemistry2020
A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues.
Article in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans.Open biology · 2025Article
- Advances in mass spectrometry of lipids for the investigation of Niemann-pick type C disease.Lipids in health and disease · 2025Review
- A nutritionally complete pollen-replacing diet protects honeybee colonies during stressful commercial pollination-requirement for isofucosterol.Proceedings. Biological sciences · 2025Article
- Systemic analysis of lipid metabolism from individuals to multi-organism systems.Molecular omics · 2024Article
- A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids.Nature communications · 2024Article
- Circadian organization of lipid landscape is perturbed in type 2 diabetic patients.Cell reports. Medicine · 2023Article
- Sterol and lipid metabolism in bees.Metabolomics : Official journal of the Metabolomic Society · 2023Review
- An Integrated Multi-OMICS Approach Highlights Elevated Non-Esterified Fatty Acids Impact BeWo Trophoblast Metabolism and Lipid Processing.Metabolites · 2023Article
- Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice.International journal of molecular sciences · 2023Article
- The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction.Nature communications · 2022Article
- Relative Abundance of Lipid Metabolites in Spermatozoa across Three Compartments.International journal of molecular sciences · 2022Article
- Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.Communications biology · 2022Article
- Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.Communications biology · 2022Article
- A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia.Nutrition & diabetes · 2022Article
- Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma.Metabolomics : Official journal of the Metabolomic Society · 2022Article
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- The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021Article
- Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes.International journal of molecular sciences · 2021Article
- Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings' lipid metabolism.Communications biology · 2021Article
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9 authors.
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Abstract
Lipidomics is of increasing interest in studies of biological systems. However, high-throughput data collection and processing remains non-trivial, making assessment of phenotypes difficult. We describe a platform for surveying the lipid fraction for a range of tissues. These techniques are demonstrated on a set of seven different tissues (serum, brain, heart, kidney, adipose, liver, and vastus lateralis muscle) from post-weaning mouse dams that were either obese (> 12 g fat mass) or lean (<5 g fat mass). This showed that the lipid metabolism in some tissues is affected more by obesity than others. Analysis of human serum (healthy non-pregnant women and pregnant women at 28 weeks' gestation) showed that the abundance of several phospholipids differed between groups. Human placenta from mothers with high and low BMI showed that lean placentae contain less polyunsaturated lipid. This platform offers a way to map lipid metabolism with immediate application in metabolic research and elsewhere. Graphical abstract.
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