ArticleCommunications biology2020
Pathway-specific enzymes from bamboo and crop leaves biosynthesize anti-nociceptive C-glycosylated flavones.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 45 citations in OpenAlex.
- Metabolic engineering ofaBIOTECH · 2026Article
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- A model for the adaptation of Euryale ferox leaves to aquatic environments through EfCGT1-controlled flavonoid C-glycoside-specific accumulation in epidermis cells.Plant biotechnology journal · 2025Article
- Whole Genome Analysis Reveals Evolutionary History and Introgression Events in Bale Monkeys.Genes · 2024Article
- Change of Flavonoid Content in Wheatgrass in a Historic Collection of Wheat Cultivars.Antioxidants (Basel, Switzerland) · 2024Article
- Harnessing Plant Sugar Metabolism for Glycoengineering.Biology · 2023Article
- Orientin regulates the proliferation and migration of hepatocellular carcinoma cells.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Comparative Analysis of the Symbiotic Microbiota in the Chinese Mitten Crab (Microorganisms · 2023Article
- Identification of a flavonoid C-glycosyltransferase from fern species Stenoloma chusanum and the application in synthesizing flavonoid C-glycosides in Escherichia coli.Microbial cell factories · 2022Article
- Genomic-Wide Identification and Characterization of the Uridine Diphosphate Glycosyltransferase Family inPlants (Basel, Switzerland) · 2021Article
- De novo biosynthesis ofBioresources and bioprocessing · 2021Article
- Dissection of the general two-step di-Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-glycosylated flavones (CGFs) are promising candidates as anti-nociceptive compounds. The leaves of bamboo and related crops in the grass family are a largely unexploited bioresource with a wide array of CGFs. We report here pathway-specific enzymes including C-glycosyltransferases (CGTs) and P450 hydroxylases from cereal crops and bamboo species accumulating abundant CGFs. Mining of CGTs and engineering of P450s that decorate the flavonoid skeleton allowed the production of desired CGFs (with yield of 20-40 mg/L) in an Escherichia coli cell factory. We further explored the antinociceptive activity of major CGFs in mice models and identified isoorientin as the most potent, with both neuroanalgesic and anti-inflammatory effects superior to clinical drugs such as rotundine and aspirin. Our discovery of the pain-alleviating flavonoids elicited from bamboo and crop leaves establishes this previously underutilized source, and sheds light on the pathway and pharmacological mechanisms of the compounds.
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