ArticleScientific reports2020
Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XF
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Validation of metaxin-2 deficient C. elegans as a model for MandibuloAcral Dysplasia associated to mtx-2 (MADaM) syndrome.Communications biology · 2024Article
- A multi-domain snail metallothionein increases cadmium resistance and fitness in Caenorhabditis elegans.Scientific reports · 2024Article
- Why study sleep in flatworms?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- RNA Sequencing Experimental Analysis Workflow Using Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Mitochondria in the Spotlight:Cells · 2023Review
- Different effects of a perioperative single dose of dexamethasone on wound healing in mice with or without sepsis.Frontiers in surgery · 2023Article
- The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.Nature metabolism · 2022Article
- Unveiling the contribution of the reproductive system of individual Caenorhabditis elegans on oxygen consumption by single-point scanning electrochemical microscopy measurements.Analytica chimica acta · 2021Article
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Authors and funding
9 authors.
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Abstract
Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as a sublethal endpoint of toxicity. This protocol was tested by exposing 50 larval stage one C. elegans individuals for 48 h (at 20 °C) to different concentrations of two toxicants i.e. benzylcetyldimethylammonium chloride (BAC-C16) and cadmium (Cd). Following exposures, the oxygen consumption rate of the C. elegans individuals were measured using the high-throughput functionality of the Seahorse XF
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