Evidence map›Paper›PMID 32144264›Full record

ArticleNature communications2020

Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease.

Costanza L Vallerga, Futao Zhang, Javed Fowdar, Allan F McRae, Ting Qi, Marta F Nabais, Qian Zhang, Irfahan Kassam, Anjali K Henders, Leanne Wallace and 20 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 6 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 6 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
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  14. Epigenetic mechanisms of Parkinson's disease and potential epigenetic-based therapeutics.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  15. Article
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  18. Article
  19. Metformin Alone and in Combinations Alter the Methylation Patterns ofEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 7 institutions in 4 countries.

Costanza L VallergaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Futao ZhangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Javed FowdarGriffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia.ORCID http://orcid.org/0000-0003-2406-4511
Allan F McRaeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0001-5286-5485
Ting QiInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Marta F NabaisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Qian ZhangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Irfahan KassamInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Anjali K HendersInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Leanne WallaceInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Grant MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0002-4140-8139
Yu-Hsuan ChuangDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4110-3589
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
Glenda HallidayBrain and Mind Centre & Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0003-0422-8398
Ian HickieBrain and Mind Centre & Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
John B KwokBrain and Mind Centre & Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
John PearsonDepartment of Pathology, University of Otago, Christchurch, New Zealand.
Toni PitcherNew Zealand Brain Research Institute, Christchurch, New Zealand.
Martin KennedyDepartment of Pathology, University of Otago, Christchurch, New Zealand.ORCID http://orcid.org/0000-0002-6445-8526
Steven R BentleyGriffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia.
Peter A SilburnQueensland Brain Institute, The University of Queensland, Brisbane, Australia.
Jian YangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0003-2001-2474
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0001-7421-3357
Simon J G LewisBrain and Mind Centre & Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Tim AndersonNew Zealand Brain Research Institute, Christchurch, New Zealand.ORCID http://orcid.org/0000-0002-1116-3839
John Dalrymple-AlfordNew Zealand Brain Research Institute, Christchurch, New Zealand.
George D Mellick *Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia.
Peter M Visscher *Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. peter.visscher@uq.edu.au.ORCID http://orcid.org/0000-0002-2143-8760
Jacob Gratten *Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. jacob.gratten@mater.uq.edu.au.ORCID http://orcid.org/0000-0003-1293-409X
The University of Queensland · AUThe University of Sydney · AUGriffith University · AUNew Zealand Brain Research Institute · NZUniversity of California, Los Angeles · USUniversity of Otago · NZUniversity of Canterbury · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An improved understanding of etiological mechanisms in Parkinson's disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present results from a blood-based methylome-wide association study of PD involving meta-analysis of 229 K CpG probes in 1,132 cases and 999 controls from two independent cohorts. We identify two previously unreported epigenome-wide significant associations with PD, including cg06690548 on chromosome 4. We demonstrate that cg06690548 hypermethylation in PD is associated with down-regulation of the SLC7A11 gene and show this is consistent with an environmental exposure, as opposed to medications or genetic factors with effects on DNA methylation or gene expression. These findings are notable because SLC7A11 codes for a cysteine-glutamate anti-porter regulating levels of the antioxidant glutathione, and it is a known target of the environmental neurotoxin β-methylamino-L-alanine (BMAA). Our study identifies the SLC7A11 gene as a plausible biological target in PD.

Indexed as

DNA MethylationAdultAgedAged, 80 and overAmino Acid Transport System y+AustraliaCase-Control StudiesChromosomes, Human, Pair 4CpG IslandsDown-RegulationEpigenomicsFemaleGlutathioneHealthy VolunteersHumansMaleAmino Acid Transport System y+GlutathioneSLC7A11 protein, human

Identifiers

PMID32144264
PMCPMC7060318
OpenAlexW3009792486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.