Evidence map›Paper›PMID 32144180›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Contribution of NPY Y

Sheldon D Michaelson, Ana Pamela Miranda Tapia, Amanda McKinty, Heika Silveira Villarroel, James P Mackay, Janice H Urban, William F Colmers

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sheldon D MichaelsonDepartment of Pharmacology, and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, and.
Ana Pamela Miranda TapiaDepartment of Pharmacology, and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, and.
Amanda McKintyDepartment of Pharmacology, and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, and.
Heika Silveira VillarroelDepartment of Pharmacology, and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, and.
James P MackayDepartment of Pharmacology, and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, and.
Janice H UrbanCenter for the Neurobiology of Stress Resilience and Psychiatric Disorders, Discipline of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064.
William F ColmersDepartment of Pharmacology, and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, and wcolmers@ualberta.ca.
University of Alberta · CAWomen and Children’s Health Research Institute · CARosalind Franklin University of Medicine and Science · US

Funding

Mechanisms Underlying Stress ResilienceR01MH090297 · NIMH · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI URBAN, JANICE H · 2010 to 2014
$1.7M
Neuropeptide circuits and stress regulation in the basolateral amygdalaR56MH081152 · NIMH · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI URBAN, JANICE H · 2009 to 2009
$430k
NIMH NIH HHS R01 MH090297NIMH NIH HHS R56 MH081152
6 · The paper itself

Abstract

Endogenous neuropeptide Y (NPY) and corticotrophin-releasing factor (CRF) modulate the responses of the basolateral amygdala (BLA) to stress and are associated with the development of stress resilience and vulnerability, respectively. We characterized persistent effects of repeated NPY and CRF treatment on the structure and function of BLA principal neurons in a novel organotypic slice culture (OTC) model of male rat BLA, and examined the contributions of specific NPY receptor subtypes to these neural and behavioral effects. In BLA principal neurons within the OTCs, repeated NPY treatment caused persistent attenuation of excitatory input and induced dendritic hypotrophy via Y

Indexed as

Social BehaviorAnimalsBasolateral Nuclear ComplexBehavior, AnimalCalcineurinCalcium-Calmodulin-Dependent Protein Kinase Type 2Corticotropin-Releasing HormoneDendritesMaleNeuronal PlasticityNeuronsNeuropeptide YRatsRats, Sprague-DawleyReceptors, Neuropeptide YResilience, PsychologicalCalcineurinCalcium-Calmodulin-Dependent Protein Kinase Type 2Corticotropin-Releasing HormoneNeuropeptide Yneuropeptide Y5 receptorReceptors, Neuropeptide Ybasolateral amygdaladendritic plasticityNPY Y5 receptororganotypic slice culturessocial interactionstress resilience

Identifiers

PMID32144180
PMCPMC7159890
OpenAlexW3009250386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.