Evidence map›Paper›PMID 32144140›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology.

Catherine Fan, Paul A Davison, Robert Habgood, Hong Zeng, Christoph M Decker, Manuela Gesell Salazar, Khemmathin Lueangwattanapong, Helen E Townley, Aidong Yang, Ian P Thompson and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 59 citations in OpenAlex.

  1. Reprogrammed SimCells for antimicrobial therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. A Safe and Versatile Minicell Platform Derived fromJournal of microbiology and biotechnology · 2025
    Article
  3. Article
  4. Review
  5. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Leveraging EngineeredACS synthetic biology · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Journal of bacteriology · 2024
    Review
  17. Review
  18. Article
  19. Review
  20. Regulation strategies for two-output biomolecular networks.Journal of the Royal Society, Interface · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Catherine FanDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Paul A DavisonDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom.
Robert HabgoodDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Hong ZengDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Christoph M DeckerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
Manuela Gesell SalazarInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
Khemmathin LueangwattanapongDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Helen E TownleyDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Aidong YangDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Ian P ThompsonDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Hua YeDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.ORCID 0000-0001-7613-6041
Zhanfeng CuiDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.
Frank SchmidtInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
C Neil HunterDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID 0000-0003-2533-9783
Wei E HuangDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom; wei.huang@eng.ox.ac.uk.ORCID 0000-0003-1302-6528
University of Oxford · GBUniversitätsmedizin Greifswald · DEUniversity of Sheffield · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M000265/1
6 · The paper itself

Abstract

A type of chromosome-free cell called SimCells (simple cells) has been generated from

Indexed as

Cellular ReprogrammingAntineoplastic AgentsCatecholsCell ProliferationChromosomes, BacterialCupriavidus necatorDrug Delivery SystemsEscherichia coliGene Regulatory NetworksGenetic EngineeringNeoplasmsPseudomonas putidaSynthetic BiologyTumor Cells, CulturedAntineoplastic AgentscatecholCatecholsbacterial therapycancerminimal genomeSimCellssynthetic biology

Identifiers

PMID32144140
PMCPMC7104398
OpenAlexW3009922224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.