Evidence map›Paper›PMID 32144109›Full record

ArticleApplied and environmental microbiology2020

Combining Random Mutagenesis and Metabolic Engineering for Enhanced Tryptophan Production in

Arnav Deshpande, Jeremiah Vue, John Morgan

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Optimization of fermentation parameters and mutagenesis of Glarea lozoyensis ATCC 20868 towards pneumocandin BBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arnav DeshpandeDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana, USA.
Jeremiah VueDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana, USA.
John MorganDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana, USA jamorgan@purdue.edu.
Purdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tryptophan (Trp) is an essential aromatic amino acid that has value as an animal feed supplement, as the amount found in plant-based sources is insufficient. An alternative to production by engineered microbial fermentation is to have tryptophan biosynthesized by a photosynthetic microorganism that could replace or supplement both the plant and industrially used microbes. We selected

Indexed as

Gene Expression Regulation, BacterialMetabolic EngineeringMutagenesisEscherichia coliEscherichia coli ProteinsMicroorganisms, Genetically-ModifiedSynechocystisTryptophanEscherichia coli ProteinsTryptophanaromatic amino acidscyanobacteriagene overexpressionl-tryptophanmetabolic engineeringSynechocystis

Identifiers

PMID32144109
PMCPMC7170483
OpenAlexW3009829568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.